Liu Na, Yan Wei-Tao, Xiong Kun
Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 410013, Hunan Province, China.
World J Diabetes. 2025 May 15;16(5):104311. doi: 10.4239/wjd.v16.i5.104311.
Diabetes mellitus (DM) and its associated complications are metabolic disorders characterized by hyperglycemia, leading to high morbidity and reduced quality of life worldwide. This global healthcare problem imposes substantial personal and social burdens that warrant comprehensive and in-depth investigation. Plantamajoside (PMS), a naturally bioactive ingredient derived from the traditional Chinese medicinal herb , exhibits a range of pharmacological properties, including anti-inflammatory, antioxidative, and antitumor effects, and has been traditionally utilized in clinical applications such as removing phlegm and clearing heat. However, the potential biological impact of PMS on DM remains largely unexplored. Recent research by Wang reported the therapeutic potential of PMS in type 2 DM (T2DM) and elucidated the underlying molecular mechanisms. Specifically, PMS mitigates endoplasmic reticulum stress and apoptosis of pancreatic β-cells by upregulating DnaJ heat shock protein family (Hsp40) member C1, thereby alleviating pancreatic β-cell damage and ameliorating T2DM progression. Given the novel and protective effect of PMS on pancreatic β-cells, this natural ingredient emerges as an innovative and promising therapeutic strategy for improving DM outcomes. PMS has been shown to modulate key signaling pathways involved in multiple types of regulated cell death (RCD), such as apoptosis and autophagy. Various forms of RCD, including apoptosis, ferroptosis, pyroptosis, autophagy, and PANoptosis, contribute to the pathogenesis of DM and its associated complications. There is significant potential for PMS to exert protective effects on β-cells against these forms of RCD and to provide a multitarget approach to DM therapy. Therefore, further exploration into whether PMS shields pancreatic β-cells from these types of RCD, coupled with elucidating the underlying molecular mechanisms, will facilitate the development of more effective therapeutic strategies for DM. Additionally, further investigation on PMS in conjunction with other therapeutic approaches is warranted to enhance therapeutic efficacy for DM.
糖尿病（DM）及其相关并发症是特征为高血糖的代谢紊乱疾病，在全球范围内导致高发病率和生活质量下降。这一全球性医疗问题带来了巨大的个人和社会负担，值得进行全面深入的研究。Plantamajoside（PMS）是一种源自传统中草药的天然生物活性成分，具有一系列药理特性，包括抗炎、抗氧化和抗肿瘤作用，并且传统上已用于诸如祛痰清热等临床应用。然而，PMS对DM的潜在生物学影响在很大程度上仍未得到探索。Wang最近的研究报道了PMS在2型糖尿病（T2DM）中的治疗潜力，并阐明了其潜在的分子机制。具体而言，PMS通过上调DnaJ热休克蛋白家族（Hsp40）成员C1减轻内质网应激和胰腺β细胞凋亡，从而减轻胰腺β细胞损伤并改善T2DM进展。鉴于PMS对胰腺β细胞的新颖保护作用，这种天然成分成为改善DM结局创新且有前景的治疗策略。已证明PMS可调节参与多种类型程序性细胞死亡（RCD）的关键信号通路，如凋亡和自噬。各种形式的RCD，包括凋亡、铁死亡、焦亡、自噬和PANoptosis，都参与了DM及其相关并发症的发病机制。PMS有很大潜力对β细胞针对这些形式的RCD发挥保护作用，并为DM治疗提供多靶点方法。因此，进一步探究PMS是否能保护胰腺β细胞免受这些类型的RCD影响，并阐明其潜在分子机制，将有助于开发更有效的DM治疗策略。此外，有必要对PMS与其他治疗方法联合进行进一步研究，以提高DM的治疗效果。
