Zhou Yi-Mai, Cao Yuan-Hao, Guo Jing, Cen Lu-Sha
The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China.
Department of Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, Zhejiang Province, China.
World J Diabetes. 2024 Oct 15;15(10):2010-2014. doi: 10.4239/wjd.v15.i10.2010.
Current treatment strategies for diabetic retinopathy (DR), an eye condition that can lead to blindness, have mainly focused on proliferative DR, including vitreous injection, retinal photocoagulation, and vitrectomy. Vitreous injections mainly depend on anti-vascular endothelial growth factor therapy. In this editorial, we comment on the article by Sun . We focus specifically on the mechanisms of the protective effect of genipin on the retina. Genipin is a gardenia extract used in traditional Chinese medicine (TCM). In their study, the authors suggest that controlling advanced glycosylation by the intraocular injection of genipin may be a strategy for preventing retinopathy. The innovative use of a Chinese medicine extract injected into the eye to achieve a curative effect has attracted our attention. Although TCM is effective in treating DR, the topical application of DR, especially intraocular injections, is not yet feasible. Herein, we present a brief analysis of effective Chinese medicines for the treatment of DR. The effectiveness of local injections of TCM applied directly into the eyes holds promise as an effective treatment approach for DR.
糖尿病性视网膜病变（DR）是一种可导致失明的眼部疾病，目前的治疗策略主要集中在增殖性DR，包括玻璃体注射、视网膜光凝和玻璃体切除术。玻璃体注射主要依赖抗血管内皮生长因子治疗。在这篇社论中，我们对孙的文章进行评论。我们特别关注京尼平对视网膜保护作用的机制。京尼平是一种用于传统中药（TCM）的栀子提取物。在他们的研究中，作者表明通过眼内注射京尼平来控制晚期糖基化可能是预防视网膜病变的一种策略。将中药提取物注射到眼睛中以达到治疗效果的创新应用引起了我们的注意。虽然中药在治疗DR方面有效，但DR的局部应用，尤其是眼内注射，目前尚不可行。在此，我们对治疗DR的有效中药进行简要分析。直接将中药局部注射到眼睛中的有效性有望成为DR的一种有效治疗方法。
