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TRIM21-based degradation strategy for multimeric proteins.

作者信息

Wang Wei, Sheng Chunquan

机构信息

The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China.

出版信息

Acta Pharm Sin B. 2025 May;15(5):2798-2800. doi: 10.1016/j.apsb.2025.02.025. Epub 2025 Feb 24.

Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9e/12144976/434d8f439769/gr1.jpg

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本文引用的文献

1
Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders.
Cell. 2024 Dec 12;187(25):7126-7142.e20. doi: 10.1016/j.cell.2024.10.015. Epub 2024 Nov 1.
2
Expanding PROTACtable genome universe of E3 ligases.
Nat Commun. 2023 Oct 16;14(1):6509. doi: 10.1038/s41467-023-42233-2.
3
Structure and Assembly of the Nuclear Pore Complex.
Annu Rev Biophys. 2019 May 6;48:515-536. doi: 10.1146/annurev-biophys-052118-115308. Epub 2019 Apr 3.
4
Structural constraints on autoprocessing of the human nucleoporin Nup98.
Protein Sci. 2008 Mar;17(3):494-505. doi: 10.1110/ps.073311808.

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