3-(2-{3-[2-(2-氧代恶唑烷-3-基)乙氧基]喹喔啉-2-基氧基}乙基)恶唑烷-2-酮的合成与晶体结构
Synthesis and crystal structure of 3-(2-{3-[2-(2-oxooxazolidin-3-yl)eth-oxy]quinoxalin-2-yl-oxy}eth-yl)oxazolidin-2-one.
作者信息
Aboutofil Fatima Ezzahra, Mustaphi Nour El Hoda, Blacque Olivier, Hökelek Tuncer, Mazzah Ahmed, El Ghayati Lhoussaine, Sebbar Nada Kheira
机构信息
Laboratory of Heterocyclic Organic Chemistry Medicines Science Research Center Pharmacochemistry Competence Center Mohammed V University in Rabat Faculté des Sciences Av Ibn Battouta BP 1014 Rabat Morocco.
University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
出版信息
Acta Crystallogr E Crystallogr Commun. 2025 May 2;81(Pt 6):469-472. doi: 10.1107/S2056989025003755. eCollection 2025 Jun 1.
In the title compound, CHNO, one of the oxazolidine rings adopts a twisted conformation and the other is a shallow envelope. In the crystal, weak C-H⋯O hydrogen bonds and π-π stacking inter-actions help to consolidate a three-dimensional architecture. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (48.4%) and H⋯O/O⋯H (29.1%) contacts.
在标题化合物CHNO中，其中一个恶唑烷环呈扭曲构象，另一个呈浅信封式构象。在晶体中，弱的C-H⋯O氢键和π-π堆积相互作用有助于巩固三维结构。晶体结构的 Hirshfeld 表面分析表明，晶体堆积中最重要的贡献来自H⋯H（48.4%）和H⋯O/O⋯H（29.1%）接触。
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