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基于涂覆有分子印迹聚合物的磁铁矿的有机-无机磁性纳米颗粒用于药物递送系统。

Organic-Inorganic Magnetic Nanoparticles Based on Magnetite Coated with Molecularly Imprinted Polymers for Drug Delivery Systems.

作者信息

Ramírez-Rave Sandra, Antonio Gutiérrez Leticia, Rojas-Montoya Iván D, Bernad-Bernad Ma Josefa, Gracia-Mora Jesús

机构信息

Departamento de Química Inorgánica, Facultad de Química, UNAM, Avenida Universidad 3000, 04510 Ciudad de México, México.

Departamento de Farmacia, Facultad de Química, UNAM, Avenida Universidad 3000, 04510 Ciudad de México, México.

出版信息

ACS Omega. 2025 May 19;10(21):21105-21119. doi: 10.1021/acsomega.4c09515. eCollection 2025 Jun 3.

DOI:10.1021/acsomega.4c09515
PMID:40488049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12138690/
Abstract

New magnetic organic/inorganic hybrid nanoparticles were prepared by coating the magnetite surface with molecularly imprinted polymers of different monomers (methacrylic acid, itaconic acid, 1-vinylimidazole, 4-vinylpyridine). Magnetite was synthesized by coprecipitation, and polymeric coatings were induced by thermal heating and magnetic hyperthermia. The resultant nanocomposites were tested as Drug Delivery Systems (DDS) of 6-mercaptopurine (6-MP), displaying an interesting behavior depending on (a) the synthesis method used for their preparation and (b) the conditions employed for the release test. DDS based on methacrylic acid displayed the best performance in the release of 6-MP in all cases, but the rationalization of a magnetite MIP (molecularly imprinted polymer) system of this monomer enhanced the release yield by approximately 50% compared with the nonimprinted system (NIP) prepared with the same monomer. New MNP obtained are able to behave as DDS under magnetic hyperthermia with a moderate performance in contrast to the release in the absence of magnetic field.

摘要

通过用不同单体（甲基丙烯酸、衣康酸、1-乙烯基咪唑、4-乙烯基吡啶）的分子印迹聚合物包覆磁铁矿表面，制备了新型磁性有机/无机杂化纳米粒子。通过共沉淀法合成磁铁矿，并通过热加热和磁热疗诱导聚合物涂层。所得纳米复合材料作为6-巯基嘌呤（6-MP）的药物递送系统（DDS）进行了测试，其表现出有趣的行为，这取决于（a）用于制备它们的合成方法和（b）用于释放测试的条件。基于甲基丙烯酸的DDS在所有情况下6-MP的释放中表现最佳，但与用相同单体制备的非印迹系统（NIP）相比，这种单体的磁铁矿分子印迹聚合物（MIP）系统的合理化使释放产率提高了约50%。与在无磁场下的释放相比，新获得的MNP在磁热疗下能够作为DDS表现出中等性能。

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