de Araújo Laura Costa Alves, Leite Natasha Rios, da Rocha Paola Dos Santos, Oliveira Alex Santos, Leite Daniel Ferreira, Estigarribia Isabella Giunco, Alves Matheus Henrique Franco, Soutilha Alércio da Silva, Dos Santos Helder Freitas, Baldivia Debora da Silva, Junior Nelson Carvalho Farias, Agarrayua Danielle Araujo, de Ávila Daiana Silva, Campos Jaqueline Ferreira, de Picoli Souza Kely, Dos Santos Edson Lucas
Research Group on Biotechnology and Bioprospecting Applied to Metabolism and Cancer (GEBBAM) Federal University of Grande Dourados Dourados Mato Grosso do Sul Brazil.
Research Group in Biochemistry and Toxicology in Caenorhabditis elegans Federal University of Pampa Uruguaiana Rio Grande do Sul Brazil.
Food Sci Nutr. 2025 Jun 7;13(6):e70384. doi: 10.1002/fsn3.70384. eCollection 2025 Jun.
The Camb. is a native Brazilian Cerrado species, considered the symbol of this biome. This tree produces a fruit known as pequi, which is much appreciated in Brazilian traditional culinary and is also used in popular medicine. However, there is still limited knowledge about the pharmaceutical potential of the fruit of . In this study, we evaluated the bioactive compounds present in the lyophilized fruit pulp of (CBFP) and investigated its antioxidant properties in vitro and in vivo, as well as its effects on models of Alzheimer's disease and longevity. As a main result, we revealed that CBFP presented phenolic and flavonoid constituents, lipophilic compounds, and ascorbic acid. The in vitro antioxidant activity was observed through free radical scavenging and DNA protection against oxidative damage. In the in vivo life quality assay, no signs of CBFP-induced toxicity were observed, and nematode viability and reproductive capacity remained unaltered. Furthermore, CBFP treatment delayed paralysis in the Alzheimer's disease mutant strain and improved locomotor capacity during aging in the wild-type strain. CBFP increased the lifespan of and enhanced resistance to oxidative and heat stresses. Together, our findings demonstrate that CBFP exhibited beneficial effects on healthspan, attributed to its antioxidant properties and the regulation of oxidative stress.
坎布树是一种原产于巴西塞拉多的物种，被视为该生物群落的象征。这种树结出一种名为佩基的果实，在巴西传统烹饪中备受青睐，在民间医学中也有应用。然而，对于坎布树果实的药用潜力仍知之甚少。在本研究中，我们评估了坎布树冻干果实果肉（CBFP）中存在的生物活性化合物，并在体外和体内研究了其抗氧化特性，以及它对阿尔茨海默病模型和寿命的影响。作为主要结果，我们发现CBFP含有酚类和黄酮类成分、亲脂性化合物以及抗坏血酸。通过自由基清除和DNA氧化损伤保护观察到了体外抗氧化活性。在体内生活质量测定中，未观察到CBFP诱导毒性的迹象，线虫的活力和繁殖能力保持不变。此外，CBFP处理延缓了阿尔茨海默病突变株的麻痹，并改善了野生型株衰老过程中的运动能力。CBFP延长了线虫的寿命，并增强了其对氧化应激和热应激的抵抗力。总之，我们的研究结果表明，CBFP因其抗氧化特性和氧化应激调节作用而对健康寿命产生有益影响。
