PET和尸检分析揭示了晚年情绪障碍中多样的tau病理特征。
Diverse tau pathologies in late-life mood disorders revealed by PET and autopsy assays.
作者信息
Kurose Shin, Moriguchi Sho, Kubota Manabu, Tagai Kenji, Momota Yuki, Ichihashi Masanori, Sano Yasunori, Endo Hironobu, Hirata Kosei, Kataoka Yuko, Goto Ryoji, Mashima Yuki, Yamamoto Yasuharu, Suzuki Hisaomi, Nakajima Shinichiro, Mizutani Masashi, Sano Terunori, Kawamura Kazunori, Zhang Ming-Rong, Tatebe Harutsugu, Tokuda Takahiko, Onaya Mitsumoto, Mimura Masaru, Sahara Naruhiko, Takahashi Hidehiko, Uchida Hiroyuki, Takao Masaki, Meyer Jeffrey H, Higuchi Makoto, Takahata Keisuke
机构信息
Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
出版信息
Alzheimers Dement. 2025 Jun;21(6):e70195. doi: 10.1002/alz.70195.
INTRODUCTION
Late-life mood disorders (LLMDs) may represent prodromal manifestations of neurodegenerative dementia; however, the neuropathological basis of LLMDs, including depression and bipolar disorder, remains unclear. We aimed to investigate the involvement of Alzheimer's disease (AD) and non-AD tau pathologies in LLMD participants.
METHODS
Fifty-two LLMD participants and 47 age- and sex-matched healthy controls (HCs) underwent tau and amyloid beta (Aβ) positron emission tomography (PET) imaging using F-florzolotau and C-Pittsburgh compound B. Additionally, we conducted a clinicopathological correlation analysis in 208 autopsy cases, including various neurodegenerative diseases.
RESULTS
LLMD participants were more likely to be tau PET and Aβ PET positive than HCs. The PET results were supported by the post mortem results that showed a higher likelihood of diverse tauopathies in patients with late-life mania or depression than those without.
DISCUSSION
Our PET and autopsy assays suggest that AD and diverse non-AD tau pathologies might underlie the neuropathological basis of some LLMD cases.
HIGHLIGHTS
Late-life mood disorders (LLMDs) may represent prodromal states of dementia. The neuropathological basis of LLMDs remains unclear. LLMD subjects were highly likely to be tau positron emission tomography (PET) positive. Brain bank data supported our PET results. Alzheimer's disease (AD) and diverse non-AD tau pathologies can contribute to LLMDs.
引言
晚年情绪障碍（LLMDs）可能是神经退行性痴呆的前驱表现；然而，包括抑郁症和双相情感障碍在内的LLMDs的神经病理学基础仍不清楚。我们旨在研究阿尔茨海默病（AD）和非AD tau病变在LLMD参与者中的情况。
方法
52名LLMD参与者和47名年龄和性别匹配的健康对照者（HCs）使用F-florzolotau和C-匹兹堡化合物B进行了tau和淀粉样β蛋白（Aβ）正电子发射断层扫描（PET）成像。此外，我们对208例尸检病例进行了临床病理相关性分析，包括各种神经退行性疾病。
结果
与HCs相比，LLMD参与者更有可能tau PET和Aβ PET呈阳性。PET结果得到了尸检结果的支持，尸检结果显示，晚年躁狂或抑郁患者出现各种tau病变的可能性高于无此类症状的患者。
讨论
我们的PET和尸检分析表明，AD和各种非AD tau病变可能是一些LLMD病例神经病理学基础的原因。
要点
晚年情绪障碍（LLMDs）可能代表痴呆的前驱状态。LLMDs的神经病理学基础仍不清楚。LLMD受试者极有可能tau正电子发射断层扫描（PET）呈阳性。脑库数据支持了我们的PET结果。阿尔茨海默病（AD）和各种非AD tau病变可导致LLMDs。
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