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[白血病患儿维生素D缺乏症与骨代谢生化指标]

[Hypovitaminosis D and biochemical parameters of bone metabolism in children with leukemia].

作者信息

Barbosa-Cortés Lourdes, Atilano-Miguel Salvador, Cortés-Beltrán Víctor Manuel, Morales-Montes Sharon Berenice, Martín-Trejo Jorge Alfonso, Maldonado-Hernández Jorge, Domínguez-Salgado Juan Manuel

机构信息

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Pediatría "Dr. "Silvestre Frenk Freund", Unidad de Investigación Médica en Nutrición. Ciudad de México, México.

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Pediatría "Dr. "Silvestre Frenk Freund", Departamento de Hematología Pediátrica. Ciudad de México, México.

出版信息

Rev Med Inst Mex Seguro Soc. 2025 Jan 2;63(Suppl 1):e6482. doi: 10.5281/zenodo.14199833.

DOI:10.5281/zenodo.14199833
PMID:40489712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12151548/
Abstract

INTRODUCTION

25(OH)D is key for maintaining bone health. Treatment of pediatric patients with acute lymphoblastic leukemia (ALL) has a negative effect on bone metabolism.

OBJECTIVE

To describe the frequency of hypovitaminosis D, changes in serum 25(OH)D concentrations, and the biochemical and hormonal markers of bone metabolism between diagnosis and referral in children with ALL.

MATERIAL AND METHODS

Prospective, longitudinal, cohort study in pediatric patients (4-17 years) with newly diagnosed B-cell ALL, and without treatment. Patients were summoned under fasting conditions, and a peripheral blood sample was taken to determine 25(OH)D, parathyroid hormone (PTH), phosphorus, and ionic calcium concentrations.

RESULTS

Of the 40 patients recruited, 7 were lost to follow-up, so only 33 were analyzed. 91% of the children had hypovitaminosis D. We observed a significant increase in ionic calcium concentrations from baseline levels (1.1 mmol/L vs. 1.2 mmol/L, p = 0.002). Analysis of the Δ of serum PTH and 25(OH)D concentrations showed an inverse relationship (rho = -0.397, p = 0.024).

CONCLUSIONS

These findings confirm a high frequency of hypovitaminosis D. Low 25(OH)D levels may compromise calcium absorption and generate a compensatory increase in PTH.

摘要

引言

25(OH)D对维持骨骼健康至关重要。急性淋巴细胞白血病（ALL）患儿的治疗会对骨代谢产生负面影响。

目的

描述ALL患儿从诊断到转诊期间维生素D缺乏症的发生率、血清25(OH)D浓度变化以及骨代谢的生化和激素标志物。

材料与方法

对新诊断为B细胞ALL且未接受治疗的儿科患者（4 - 17岁）进行前瞻性、纵向队列研究。患者在空腹条件下前来，采集外周血样本以测定25(OH)D、甲状旁腺激素（PTH）、磷和离子钙浓度。

结果

在招募的40例患者中，7例失访，因此仅分析了33例。91%的儿童患有维生素D缺乏症。我们观察到离子钙浓度较基线水平显著升高（1.1 mmol/L对1.2 mmol/L，p = 0.002）。血清PTH和25(OH)D浓度变化的分析显示出负相关关系（rho = -0.397，p = 0.024）。

结论

这些发现证实维生素D缺乏症的发生率很高。低水平的25(OH)D可能会损害钙的吸收并导致PTH代偿性增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/9a155d95470d/04435117-63-Suppl1-e6482-f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/5863b4c945fe/04435117-63-Suppl1-e6482-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/1ab348094c4b/04435117-63-Suppl1-e6482-c001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/ec374c6faf4e/04435117-63-Suppl1-e6482-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/e72d37546f47/04435117-63-Suppl1-e6482-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/864d65fa5831/04435117-63-Suppl1-e6482-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/9a155d95470d/04435117-63-Suppl1-e6482-f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/5863b4c945fe/04435117-63-Suppl1-e6482-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/1ab348094c4b/04435117-63-Suppl1-e6482-c001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/a3077e9a57a0/04435117-63-Suppl1-e6482-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/ec374c6faf4e/04435117-63-Suppl1-e6482-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/e72d37546f47/04435117-63-Suppl1-e6482-f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/864d65fa5831/04435117-63-Suppl1-e6482-f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/12151548/9a155d95470d/04435117-63-Suppl1-e6482-f006.jpg

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本文引用的文献

1
Vitamin D status in Mexican children 1 to 11 years of age: an update from the Ensanut 2018-19.墨西哥 1 至 11 岁儿童的维生素 D 状况：来自 Ensanut 2018-19 的最新数据。
Salud Publica Mex. 2021 May 3;63(3 May-Jun):382-393. doi: 10.21149/12156.
2
Parathyroid hormone.甲状旁腺激素。
Adv Clin Chem. 2021;101:41-93. doi: 10.1016/bs.acc.2020.06.005. Epub 2020 Jul 20.
3
Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study.维生素 K2 和维生素 D3 对急性淋巴细胞白血病患儿骨密度的影响：一项前瞻性队列研究。
J Pediatr Endocrinol Metab. 2021 Feb 25;34(4):441-447. doi: 10.1515/jpem-2020-0637. Print 2021 Apr 27.
4
Bone Mineral Metabolism During Chemotherapy in Childhood Acute Lymphoblastic Leukemia.儿童急性淋巴细胞白血病化疗期间的骨矿物质代谢。
J Pediatr Hematol Oncol. 2021 Jul 1;43(5):172-175. doi: 10.1097/MPH.0000000000001908.
5
Prevalence of vitamin D deficiency in childhood acute lymphoblastic leukemia and its association with adverse outcomes during induction phase of treatment.儿童急性淋巴细胞白血病中维生素 D 缺乏的患病率及其与诱导治疗期间不良结局的关系。
Nutr Cancer. 2020;72(8):1321-1325. doi: 10.1080/01635581.2019.1679196. Epub 2019 Oct 22.
6
Severity of reduced bone mineral density and risk of fractures in long-term survivors of childhood leukemia and lymphoma undergoing guideline-recommended surveillance for bone health.儿童期白血病和淋巴瘤长期幸存者在接受推荐的骨骼健康监测时，其骨密度降低的严重程度和骨折风险。
Cancer. 2020 Jan 1;126(1):202-210. doi: 10.1002/cncr.32512. Epub 2019 Sep 19.
7
Prediction of Low and Very Low Bone Mineral Density Among Adult Survivors of Childhood Cancer.儿童期癌症幸存者的低骨密度和极低骨密度预测。
J Clin Oncol. 2019 Sep 1;37(25):2217-2225. doi: 10.1200/JCO.18.01917. Epub 2019 May 31.
8
Skeletal Morbidity in Children and Adolescents during and following Cancer Therapy.儿童和青少年癌症治疗期间和治疗后的骨骼发病率。
Horm Res Paediatr. 2019;91(2):137-151. doi: 10.1159/000494809. Epub 2018 Nov 27.
9
Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low- and middle-income countries.全球维生素 D 缺乏症的患病率和疾病负担：在中低收入国家采取行动的路线图。
Ann N Y Acad Sci. 2018 Oct;1430(1):44-79. doi: 10.1111/nyas.13968. Epub 2018 Sep 18.
10
Bone Morbidity and Recovery in Children With Acute Lymphoblastic Leukemia: Results of a Six-Year Prospective Cohort Study.儿童急性淋巴细胞白血病的骨质发病率和恢复情况：一项为期六年的前瞻性队列研究结果。
J Bone Miner Res. 2018 Aug;33(8):1435-1443. doi: 10.1002/jbmr.3447. Epub 2018 May 22.