儿童和青少年癌症治疗期间和治疗后的骨骼发病率。
Skeletal Morbidity in Children and Adolescents during and following Cancer Therapy.
机构信息
Department of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA,
Department of Pediatrics, The Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
出版信息
Horm Res Paediatr. 2019;91(2):137-151. doi: 10.1159/000494809. Epub 2018 Nov 27.
Abstract
Skeletal abnormalities are common in children and adolescents diagnosed and treated for a malignancy. The spectrum ranges from mild pain to debilitating osteonecrosis and fractures. In this review, we summarize the impact of cancer therapy on the developing skeleton, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life in childhood cancer survivors.
摘要
骨骼异常在被诊断和治疗恶性肿瘤的儿童和青少年中很常见。其范围从轻微疼痛到使人衰弱的骨坏死和骨折。在这篇综述中，我们总结了癌症治疗对发育中骨骼的影响，提供了预防和治疗的治疗策略的最新进展，并讨论了肌肉骨骼研究的最新进展。早期识别骨骼异常和优化骨骼健康的策略对于预防儿童癌症幸存者的长期骨骼后遗症和生活质量下降至关重要。
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