• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[二十二碳六烯酸和花生四烯酸的围产期益处及建议]

[Perinatal benefits and recommendations of docosahexaenoic acid and arachidonic acid].

作者信息

Cervantes-De Celis Karla Xcaret, Fuentes-Montoya Raquel, Bernabe-García Mariela

机构信息

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Unidad de Investigación Médica en Nutrición. Ciudad de México, México.

出版信息

Rev Med Inst Mex Seguro Soc. 2025 Jan 2;63(Suppl 1):e6483. doi: 10.5281/zenodo.14199904.

DOI:10.5281/zenodo.14199904
PMID:40489713
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12164896/
Abstract

BACKGROUND

Docosahexaenoic acid (DHA) and arachidonic acid (AA) are fatty acids, part of the human milk composition. Their concentrations depend on maternal diet and endogenous supply, but recommended levels are not often reached.

OBJECTIVE

Support with evidence the DHA and AA benefits and recommendations for the infant, during pregnancy and breastfeeding.

MATERIAL AND METHODS

Narrative review. Search was made using the keywords: recomendaciones, inflamación, inmunidad, ácidos grasos, omega-3, DHA, leche materna, pretérmino, embarazo, recién nacido, suplementación; as well LC-PUFA, human milk, preterm, immunity, DHA, pregnancy, supplementation, recommendations, from 2020-2024; if there was no information in this period, the up-to-date reference was reported.

RESULTS

DHA recommendations during pregnancy and breastfeeding: 200-450 mg/day; if the DHA tissue reserve was low in pregnancy, administer 1,000 mg/day. In the preterm infant: 30-100 mg of AA/kg/day; 30-65 mg of DHA/kg/day. Infant 7-23 months 100 mg of DHA/kg/day. Covering the supply through food or supplements during gestation and after birth improves the development and functioning of the immune, brain, and visual systems in the child, modulates the inflammatory response, and reduces the risk of premature birth and neonatal diseases.

CONCLUSION

Assuring the DHA and AA supply promotes optimal development and may prevent diseases in the infant.

摘要

背景

二十二碳六烯酸（DHA）和花生四烯酸（AA）是脂肪酸，是人乳成分的一部分。它们的浓度取决于母亲的饮食和内源性供应，但推荐水平往往难以达到。

目的

为孕期和哺乳期婴儿补充DHA和AA的益处及建议提供证据支持。

材料与方法

叙述性综述。使用关键词进行搜索：recomendaciones、inflamación、inmunidad、ácidos grasos、omega-3、DHA、leche materna、pretérmino、embarazo、recién nacido、suplementación；以及LC-PUFA、human milk、preterm、immunity、DHA、pregnancy、supplementation、recommendations，检索时间为2020 - 2024年；如果该时间段内没有相关信息，则报告最新参考文献。

结果

孕期和哺乳期DHA的推荐摄入量：200 - 450毫克/天；如果孕期DHA组织储备较低，则给予1000毫克/天。早产儿：30 - 100毫克AA/千克/天；30 - 65毫克DHA/千克/天。7 - 23个月婴儿：100毫克DHA/千克/天。在孕期和出生后通过食物或补充剂满足这些营养素供应，可改善儿童免疫、大脑和视觉系统的发育与功能，调节炎症反应，并降低早产和新生儿疾病的风险。

结论

确保DHA和AA的供应可促进婴儿的最佳发育，并可能预防疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be8/12164896/73b48a905b97/04435117-63-Suppl1-e6483-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be8/12164896/818736f19722/04435117-63-Suppl1-e6483-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be8/12164896/73b48a905b97/04435117-63-Suppl1-e6483-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be8/12164896/818736f19722/04435117-63-Suppl1-e6483-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be8/12164896/73b48a905b97/04435117-63-Suppl1-e6483-f002.jpg

相似文献

1
[Perinatal benefits and recommendations of docosahexaenoic acid and arachidonic acid].[二十二碳六烯酸和花生四烯酸的围产期益处及建议]
Rev Med Inst Mex Seguro Soc. 2025 Jan 2;63(Suppl 1):e6483. doi: 10.5281/zenodo.14199904.
2
Long chain polyunsaturated fatty acid supplementation in infants born at term.足月出生婴儿补充长链多不饱和脂肪酸
Cochrane Database Syst Rev. 2017 Mar 10;3(3):CD000376. doi: 10.1002/14651858.CD000376.pub4.
3
Longchain polyunsaturated fatty acid supplementation in preterm infants.早产儿补充长链多不饱和脂肪酸
Cochrane Database Syst Rev. 2016 Dec 20;12(12):CD000375. doi: 10.1002/14651858.CD000375.pub5.
4
Iodine supplementation for women during the preconception, pregnancy and postpartum period.孕前、孕期及产后女性的碘补充
Cochrane Database Syst Rev. 2017 Mar 5;3(3):CD011761. doi: 10.1002/14651858.CD011761.pub2.
5
Cup feeding versus other forms of supplemental enteral feeding for newborn infants unable to fully breastfeed.对于无法完全进行母乳喂养的新生儿，奶瓶喂养与其他形式的补充肠内喂养的比较。
Cochrane Database Syst Rev. 2016 Aug 31;2016(8):CD005092. doi: 10.1002/14651858.CD005092.pub3.
6
Multiple-micronutrient supplementation for women during pregnancy.孕期女性的多种微量营养素补充
Cochrane Database Syst Rev. 2017 Apr 13;4(4):CD004905. doi: 10.1002/14651858.CD004905.pub5.
7
Fat supplementation of human milk for promoting growth in preterm infants.补充脂肪以促进早产儿生长。
Cochrane Database Syst Rev. 2018 Jun 19;6(6):CD000341. doi: 10.1002/14651858.CD000341.pub2.
8
Avoidance of bottles during the establishment of breastfeeds in preterm infants.避免早产儿使用奶瓶进行母乳喂养。
Cochrane Database Syst Rev. 2021 Oct 21;10(10):CD005252. doi: 10.1002/14651858.CD005252.pub5.
9
Aspirin (single dose) for perineal pain in the early postpartum period.产后早期使用阿司匹林（单次剂量）治疗会阴部疼痛。
Cochrane Database Syst Rev. 2017 Feb 9;2(2):CD012129. doi: 10.1002/14651858.CD012129.pub2.
10
Calcium supplementation commencing before or early in pregnancy, or food fortification with calcium, for preventing hypertensive disorders of pregnancy.在怀孕前或怀孕早期开始补钙，或对食物进行钙强化，以预防妊娠期高血压疾病。
Cochrane Database Syst Rev. 2017 Sep 26;9(9):CD011192. doi: 10.1002/14651858.CD011192.pub2.

本文引用的文献

1
Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development.围产期接触全氟辛烷磺酸和持续高脂肪饮食通过与神经运动发育相关的途径的基因组重编程促进神经发育障碍。
Ecotoxicol Environ Saf. 2024 Mar 1;272:116070. doi: 10.1016/j.ecoenv.2024.116070. Epub 2024 Feb 9.
2
Current Guidelines on Fat Intake in Pregnant and Lactating Women, Infants, Children, and Adolescents: A Scoping Review.当前孕妇和哺乳期妇女、婴儿、儿童和青少年脂肪摄入指南：范围综述。
Ann Nutr Metab. 2024;80(1):1-20. doi: 10.1159/000535527. Epub 2023 Dec 12.
3
Docosahexaenoic Acid Supplementation in Lactating Women Increases Breast Milk and Erythrocyte Membrane Docosahexaenoic Acid Concentrations and Alters Infant n-6:n-3 Fatty Acid Ratio.
哺乳期妇女补充二十二碳六烯酸可提高母乳和红细胞膜中二十二碳六烯酸的浓度，并改变婴儿的n-6:n-3脂肪酸比例。
Curr Dev Nutr. 2023 Sep 29;7(10):102010. doi: 10.1016/j.cdnut.2023.102010. eCollection 2023 Oct.
4
Essential Fatty Acid Supplementation and Early Inflammation in Preterm Infants: Secondary Analysis of a Randomized Clinical Trial.必需脂肪酸补充与早产儿的早期炎症：一项随机临床试验的二次分析。
Neonatology. 2023;120(4):465-472. doi: 10.1159/000530129. Epub 2023 Apr 28.
5
Omega-3 and Omega-6 Polyunsaturated Fatty Acid Intakes, Determinants and Dietary Sources in the Spanish Population: Findings from the ANIBES Study.ω-3 和 ω-6 多不饱和脂肪酸的摄入量、决定因素和膳食来源在西班牙人群中：来自 ANIBES 研究的结果。
Nutrients. 2023 Jan 21;15(3):562. doi: 10.3390/nu15030562.
6
Promising Sources of Plant-Derived Polyunsaturated Fatty Acids: A Narrative Review.具有前景的植物源多不饱和脂肪酸来源：一篇叙述性综述。
Int J Environ Res Public Health. 2023 Jan 17;20(3):1683. doi: 10.3390/ijerph20031683.
7
Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts.早产儿肠内营养（2022）：ESP-GHAN 营养委员会及特邀专家的立场文件。
J Pediatr Gastroenterol Nutr. 2023 Feb 1;76(2):248-268. doi: 10.1097/MPG.0000000000003642. Epub 2022 Oct 28.
8
ISSFAL statement number 7 - Omega-3 fatty acids during pregnancy to reduce preterm birth.ISSFAL 声明 7 - 孕期摄入欧米伽-3 脂肪酸以降低早产风险。
Prostaglandins Leukot Essent Fatty Acids. 2022 Nov;186:102495. doi: 10.1016/j.plefa.2022.102495. Epub 2022 Sep 30.
9
Marine pollutant exposures and human milk extracellular vesicle-microRNAs in a mother-infant cohort from the Faroe Islands.来自法罗群岛的母婴队列中海洋污染物暴露与母乳细胞外囊泡 microRNAs 的关系
Environ Int. 2022 Jan;158:106986. doi: 10.1016/j.envint.2021.106986. Epub 2021 Nov 20.
10
Association of Docosahexaenoic Acid and Arachidonic Acid Serum Levels With Retinopathy of Prematurity in Preterm Infants.二十二碳六烯酸和花生四烯酸血清水平与早产儿视网膜病变的关系。
JAMA Netw Open. 2021 Oct 1;4(10):e2128771. doi: 10.1001/jamanetworkopen.2021.28771.