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[二十二碳六烯酸和花生四烯酸的围产期益处及建议]

[Perinatal benefits and recommendations of docosahexaenoic acid and arachidonic acid].

作者信息

Cervantes-De Celis Karla Xcaret, Fuentes-Montoya Raquel, Bernabe-García Mariela

机构信息

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Unidad de Investigación Médica en Nutrición. Ciudad de México, México.

出版信息

Rev Med Inst Mex Seguro Soc. 2025 Jan 2;63(Suppl 1):e6483. doi: 10.5281/zenodo.14199904.

Abstract

BACKGROUND

Docosahexaenoic acid (DHA) and arachidonic acid (AA) are fatty acids, part of the human milk composition. Their concentrations depend on maternal diet and endogenous supply, but recommended levels are not often reached.

OBJECTIVE

Support with evidence the DHA and AA benefits and recommendations for the infant, during pregnancy and breastfeeding.

MATERIAL AND METHODS

Narrative review. Search was made using the keywords: recomendaciones, inflamación, inmunidad, ácidos grasos, omega-3, DHA, leche materna, pretérmino, embarazo, recién nacido, suplementación; as well LC-PUFA, human milk, preterm, immunity, DHA, pregnancy, supplementation, recommendations, from 2020-2024; if there was no information in this period, the up-to-date reference was reported.

RESULTS

DHA recommendations during pregnancy and breastfeeding: 200-450 mg/day; if the DHA tissue reserve was low in pregnancy, administer 1,000 mg/day. In the preterm infant: 30-100 mg of AA/kg/day; 30-65 mg of DHA/kg/day. Infant 7-23 months 100 mg of DHA/kg/day. Covering the supply through food or supplements during gestation and after birth improves the development and functioning of the immune, brain, and visual systems in the child, modulates the inflammatory response, and reduces the risk of premature birth and neonatal diseases.

CONCLUSION

Assuring the DHA and AA supply promotes optimal development and may prevent diseases in the infant.

摘要

背景

二十二碳六烯酸(DHA)和花生四烯酸(AA)是脂肪酸,是人乳成分的一部分。它们的浓度取决于母亲的饮食和内源性供应,但推荐水平往往难以达到。

目的

为孕期和哺乳期婴儿补充DHA和AA的益处及建议提供证据支持。

材料与方法

叙述性综述。使用关键词进行搜索:recomendaciones、inflamación、inmunidad、ácidos grasos、omega-3、DHA、leche materna、pretérmino、embarazo、recién nacido、suplementación;以及LC-PUFA、human milk、preterm、immunity、DHA、pregnancy、supplementation、recommendations,检索时间为2020 - 2024年;如果该时间段内没有相关信息,则报告最新参考文献。

结果

孕期和哺乳期DHA的推荐摄入量:200 - 450毫克/天;如果孕期DHA组织储备较低,则给予1000毫克/天。早产儿:30 - 100毫克AA/千克/天;30 - 65毫克DHA/千克/天。7 - 23个月婴儿:100毫克DHA/千克/天。在孕期和出生后通过食物或补充剂满足这些营养素供应,可改善儿童免疫、大脑和视觉系统的发育与功能,调节炎症反应,并降低早产和新生儿疾病的风险。

结论

确保DHA和AA的供应可促进婴儿的最佳发育,并可能预防疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be8/12164896/818736f19722/04435117-63-Suppl1-e6483-f001.jpg

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