亚洲地区可归因于阿尔茨海默病和其他痴呆症的风险因素负担及其与社会人口指数的关系。

Burden of risk factors attributable to Alzheimer's disease and other dementia and its relationship with the Socio-Demographic index in Asia.

作者信息

Sheikhi Kazhaal, Momenabadi Victoria, Khosravi Saman, Souri Amirhuoseen, Goodarzi Elham

机构信息

Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Department of Public Health, School of Health, Bam University of Medical Sciences, Bam, Iran.

出版信息

BMC Neurol. 2025 Jun 9;25(1):247. doi: 10.1186/s12883-025-04265-7.

DOI:10.1186/s12883-025-04265-7

PMID:40490709

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12147307/

Abstract

BACKGROUND

Dementia is an increasingly significant public health challenge worldwide, with Alzheimer’s disease being the most prevalent form of dementia. The objective of this study was burden of risk factors attributable to Alzheimer’s disease and other dementia and its relationship with the Socio-Demographic Index in Asian countries.

METHODS

The present study is a population-based study. The 2021 Global Burden of Disease Study dataset for countries in the Asian continent was used in this study. Age-standardized rate (ASR) for incidence, mortality, prevalence, Disability-Adjusted Life Years (DALY), Years of Life Lost (YLL), Years Lived with Disability (YLD) and Annual Percentage Change (APC) were considered by gender and country. We assessed the trend for all index from 2010 to 2021. In addition, the association between socio-demographic index (SDI) and Alzheimer’s disease incidence and prevalnce was calculated using Pearson correlation analysis.

RESULTS

The results indicated that the number and ASR of four indicators (incidence, prevalence, mortality, DALY, YLL, and YLD) from 1990 to 2021 were higher for women than for men. Metabolic risks and high fasting plasma glucose emerged as the primary risk factors for all four indicators. The percentage change in the risk factor associated with smoking for all four indicators decreased from 1990 to 2021, while the most significant increase was observed in the percentage change related to high body mass index. Additionally, the results demonstrated a positive and significant correlation between the Sociodemographic Index (SDI) and Age-Standardized Incidence Rate (ASIR) ( = 0.284, = 0.04) as well as Age-Standardized Prevalence Rate (ASPR) ( = 0.281, = 0.01).

CONCLUSION

According to the reported results, the burden of disease remains high in most countries. To alleviate this burden, it is essential to prioritize women and the elderly, and to implement more effective prevention and treatment measures.

摘要

背景

痴呆症是全球范围内日益严峻的公共卫生挑战，阿尔茨海默病是最常见的痴呆症形式。本研究的目的是探讨亚洲国家中可归因于阿尔茨海默病和其他痴呆症的风险因素负担及其与社会人口指数的关系。

方法

本研究是一项基于人群的研究。本研究使用了2021年亚洲大陆各国的全球疾病负担研究数据集。按性别和国家考虑了发病率、死亡率、患病率、伤残调整生命年（DALY）、生命损失年数（YLL）、带病生存年数（YLD）和年度百分比变化（APC）的年龄标准化率（ASR）。我们评估了2010年至2021年所有指标的趋势。此外，使用Pearson相关分析计算社会人口指数（SDI）与阿尔茨海默病发病率和患病率之间的关联。

结果

结果表明，1990年至2021年，女性的四项指标（发病率、患病率、死亡率、DALY、YLL和YLD）的数量和ASR高于男性。代谢风险和高空腹血糖是所有四项指标的主要风险因素。1990年至2021年，与吸烟相关的所有四项指标的风险因素百分比变化均下降，而与高体重指数相关的百分比变化增幅最大。此外，结果表明社会人口指数（SDI）与年龄标准化发病率（ASIR）（r = 0.284，p = 0.04）以及年龄标准化患病率（ASPR）（r = 0.281，p = 0.01）之间存在正相关且显著相关。