Yakubu Amin, Patel Neil V, Orru Emanuele, Pace Jonathan, Krings Timo
Division of Neurology, Lahey Hospital & Medical Center - Beth Israel Lahey Health, Tufts University Medical School, Boston, MA, USA.
Division of Neurointerventional Radiology, Lahey Hospital & Medical Center - Beth Israel Lahey Health, UMass Chan Medical School, Boston, MA, USA.
Interv Neuroradiol. 2025 Jun 10:15910199251342424. doi: 10.1177/15910199251342424.
We report the case of a 38-year-old female with alcohol-related cirrhosis who developed a de novo left hemispheric sylvian fissure pial arteriovenous malformation (AVM) causing recurrent hemorrhages, ultimately necessitating neurosurgical intervention. The case underscores the interplay between chronic systemic disease and vascular abnormalities. We explore the theory of de novo brain AVM (bAVM) formation in the context of liver cirrhosis, chronic inflammation and pro-angiogenic conditions thus shedding a light on the potential underlying pathological mechanisms of bAVM formation. This case also highlights the challenges of managing concurrent neurovascular and systemic conditions.
我们报告了一例38岁患有酒精性肝硬化的女性病例，该患者新发左半球外侧裂软膜动静脉畸形（AVM），导致反复出血，最终需要神经外科干预。该病例强调了慢性全身性疾病与血管异常之间的相互作用。我们在肝硬化、慢性炎症和促血管生成条件的背景下探讨了新发脑动静脉畸形（bAVM）形成的理论，从而揭示了bAVM形成潜在的病理机制。该病例还凸显了同时管理神经血管和全身性疾病的挑战。
