Boeskorova Sargylana, Afonskaya Marina, Argunova Vera, Sleptsova Polina, Leonteva Liudmila, Burtseva Tatiana, Kostik Mikhail Mikhailovich
Department of Pediatry and Pediatric Surgery, North-Eastern Federal University named after M.K. Ammosov, Medical Institute, Yakutsk 677000, Republic of Sakha (Yakutia), Russia.
Department of Pediatric Rheumatology, Republican Hospital No. 1 -National Center of Medicine Named After M.E. Nikolaev, Yakutsk 677019, Republic of Sakha (Yakutia), Russia.
World J Clin Pediatr. 2025 Jun 9;14(2):101873. doi: 10.5409/wjcp.v14.i2.101873.
Prevalence of the main rheumatic diseases in the Republic of Sakha (Yakutia) [RS(Y)], one of the regions of the Russian Federation, differs from the other regions of the Russian Federation due to its ethnic and geographic features. Knowledge regarding the prevalence and structure of juvenile idiopathic arthritis (JIA) allows us to shape the work of the pediatric rheumatology service in the region correctly, and optimize the healthcare system and the need for medications.
To describe the epidemiological, demographic, clinical, and laboratory characteristics of children with JIA in the RS(Y) and evaluate the main outcomes.
This retrospective cohort study assessed all the data from the medical histories of the patients ( = 225) diagnosed with JIA (2016-2023) in the Cardiorheumatology Department of the M.E. Nikolaev National Center of Medicine. Pearson's ² test, Fisher's exact test, Mann-Whitney and Kruskal-Wallis tests were used for statistical analyses.
The ethnic prevalence of JIA is higher in Sakha than in Russian children at 110.1 per 100000 children and 69.4 per 100000 children, respectively. The prevalence of JIA among boys and girls in Sakha was similar, unlike in Russians, where the number of girls predominated. The JIA categories were as follows: (1) Systemic arthritis: 3.5%; (2) Oligoarthritis (persistent and extended): 33.8%; (3) Rheumatoid factor (RF) (+) polyarthritis: 0.9%; (4) RF (-) polyarthritis: 14.7%; (5) Enthesitis-related arthritis (ERA): 44%; and (6) Psoriatic arthritis: 3.1%. Prevalence of the ERA category was 4.4 times higher in Sakha children, but the prevalence of systemic arthritis was 2.9 times lower compared to Russians ( = 0.0005). The frequency of uveitis was 10.2%, and the frequency of human leukocyte antigen (HLA) B27 was 39.6% in JIA children. Biologic treatment was received by 40.4% of JIA children and 45.3% achieved remission.
Higher JIA prevalence, male and ERA predominance, related to a higher frequency of HLA B27 are typical in RS(Y). These data might improve the pediatric rheumatology health service.
俄罗斯联邦萨哈共和国（雅库特）[RS(Y)]作为俄罗斯联邦的一个地区，由于其种族和地理特征，主要风湿性疾病的患病率与俄罗斯联邦其他地区不同。了解青少年特发性关节炎（JIA）的患病率和结构有助于我们正确规划该地区儿科风湿病服务的工作，并优化医疗保健系统和药物需求。
描述RS(Y)地区JIA患儿的流行病学、人口统计学、临床和实验室特征，并评估主要结果。
这项回顾性队列研究评估了在M.E. 尼古拉耶夫国家医学中心心脏风湿病科诊断为JIA（2016 - 2023年）的患者（n = 225）病历中的所有数据。采用Pearson卡方检验、Fisher精确检验、Mann - Whitney检验和Kruskal - Wallis检验进行统计分析。
JIA在萨哈族儿童中的患病率高于俄罗斯族儿童，分别为每10万名儿童中110.1例和69.4例。萨哈族男孩和女孩中JIA的患病率相似，而在俄罗斯族中女孩的数量占主导。JIA的类别如下：（1）全身型关节炎：3.5%；（2）少关节炎（持续性和扩展性）：33.8%；（3）类风湿因子（RF）阳性多关节炎：0.9%；（4）RF阴性多关节炎：14.7%；（5）附着点炎相关关节炎（ERA）：44%；（6）银屑病关节炎：3.1%。萨哈族儿童中ERA类别的患病率比俄罗斯族儿童高4.4倍，但全身型关节炎的患病率比俄罗斯族儿童低2.9倍（P = 0.0005）。JIA患儿葡萄膜炎的发生率为10.2%，人类白细胞抗原（HLA）B27的频率为39.6%。40.4%的JIA患儿接受了生物治疗，45.3%的患儿病情缓解。
RS(Y)地区典型的情况是JIA患病率较高、男性和ERA占主导，且与HLA B27频率较高有关。这些数据可能会改善儿科风湿病医疗服务。
