Wiedenmann Lilli C, Ehrlich Joachim R, Goldenberg Ilan
St Josefs-Hospital, Wiesbaden, Germany.
University of Rochester Medical Center, Rochester, New York, USA.
Ann Noninvasive Electrocardiol. 2025 Jul;30(4):e70079. doi: 10.1111/anec.70079.
Female LQTS patients are at high risk for arrhythmogenic events during the postpartum period due to hormonal influence on cardiac repolarization.
We observed an LQT1 patient with previous cardiac events during pregnancy and 3 weeks postpartum. We obtained ECG recordings and quantified sex hormone levels.
Peak pregnancy: QTc: 420 ± 7 ms, Estradiol: 24.18 ng/mL, Progesterone: 218 ng/mL. Seven days postpartum: QTc prolongation to 455 ± 5 ms. 22 days postpartum: QTc: 452 ± 5, Estradiol: 0.013 ng/mL, Progesterone: 0.25 ng/mL.
Estradiol and Progesterone decline rapidly after birth, correlating to QTc prolongation and elevated risk for arrhythmogenic events. Therefore, modification of pharmacological or device therapy may be considered.
由于激素对心脏复极化的影响，女性长QT综合征（LQTS）患者在产后时期发生心律失常事件的风险很高。
我们观察了一名在孕期及产后3周曾发生心脏事件的LQT1患者。我们获取了心电图记录并对性激素水平进行了定量分析。
孕期峰值：QTc：420±7毫秒，雌二醇：24.18纳克/毫升，孕酮：218纳克/毫升。产后7天：QTc延长至455±5毫秒。产后22天：QTc：452±5，雌二醇：0.013纳克/毫升，孕酮：0.25纳克/毫升。
出生后雌二醇和孕酮迅速下降，这与QTc延长及心律失常事件风险升高相关。因此，可考虑调整药物治疗或器械治疗。
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