Hall A W, Moossa A R, Pelligrini C, Clark J, Skinner D B
Am J Surg. 1977 May;133(5):544-7. doi: 10.1016/0002-9610(77)90002-2.
The lower esophageal high pressure zone (HPZ) was characterized manometrically and reflux status determined in eight male rhesus monkeys. The studies were repeated six weeks and six months after 50 per cent distal small bowel resection. At the same time fasting serum gastrin and gastric inhibitory polypeptide values were assayed. In seven animals precise antrectomy with gastroduodenal anastomosis was performed and the studies repeated. HPZ pressure increased from 6.7 +/-0.67 mm Hg (+/-1 SEM) to 10.3 +/- 0.76 mm Hg at six weeks (p less than 0.005). At six months the pressure was 9.3 +/- 1.02 mm Hg (p less than 0.02) and after antrectomy 15.2 +/- 3.1 (not significant from 6 month value, p less than 0.02 from control). Serum gastrin and GIP values showed significant elevations at six weeks, but six month and postantrectomy results were not statistically different from control. Reflux episodes for the group were reduced at six weeks and six months. After antrectomy increased reflux was noted.
对8只雄性恒河猴进行食管下高压区（HPZ）的测压特征分析并确定反流状态。在远端小肠50%切除术后6周和6个月重复这些研究。同时测定空腹血清胃泌素和胃抑制性多肽值。对7只动物进行精确的胃窦切除术并作胃十二指肠吻合术，然后重复这些研究。HPZ压力在6周时从6.7±0.67毫米汞柱（±1标准误）增加到10.3±0.76毫米汞柱（p<0.005）。6个月时压力为9.3±1.02毫米汞柱（p<0.02），胃窦切除术后为15.2±3.1（与6个月时的值无显著差异，与对照相比p<0.02）。血清胃泌素和GIP值在6周时显著升高，但6个月时和胃窦切除术后的结果与对照相比无统计学差异。该组的反流发作在6周和6个月时减少。胃窦切除术后反流增加。
