癌症中的LRG1：作用机制、潜在治疗靶点及在临床诊断中的应用
LRG1 in cancer: mechanisms, potential therapeutic target, and use in clinical diagnosis.
作者信息
Osorio-Antonio Federico, Diaz-González Daniela Michel, Bautista-Rodríguez Elizabeth, Campos-Viguri Gabriela Elizabeth, Peralta-Zaragoza Oscar, Sánchez-López José Manuel, Cortez-Sánchez José Luis, Muñoz-Olivos Cristina, Castelán Francisco, Velázquez-Orozco Verónica
机构信息
Children's Hospital of Tlaxcala, Tlaxcala, 90610, Mexico.
Faculty of Biotechnology, Popular Autonomous University of the State of Puebla, Puebla City, 72410, Mexico.
出版信息
Mol Biol Rep. 2025 Jun 10;52(1):577. doi: 10.1007/s11033-025-10669-y.
Leucine-rich alpha-2 glycoprotein 1 (LRG1) is an extracellular protein whose elevated expression has been linked to cancers with poor prognosis and low survival rates. Given its significance as a biomarker, this manuscript explores the role of LRG1 in cancer, as several studies have identified it as a promoter of proliferation, angiogenesis, invasion, and metastasis in breast, ovarian, pancreatic, and neuroblastoma cancers. However, contrasting evidence suggests that LRG1 inhibits proliferation in hepatocellular carcinoma cells and suppresses migration and invasion in esophageal squamous cell carcinoma. We also examine its regulation and the associated signaling pathways, including TGF-β and PI3K/AKT/mTOR.
富含亮氨酸的α-2糖蛋白1（LRG1）是一种细胞外蛋白，其表达升高与预后不良和生存率低的癌症有关。鉴于其作为生物标志物的重要性，本文探讨了LRG1在癌症中的作用，因为多项研究已将其确定为乳腺癌、卵巢癌、胰腺癌和神经母细胞瘤中增殖、血管生成、侵袭和转移的促进因子。然而，有相反的证据表明，LRG1抑制肝癌细胞的增殖，并抑制食管鳞状细胞癌的迁移和侵袭。我们还研究了其调控及相关信号通路，包括转化生长因子-β（TGF-β）和磷脂酰肌醇-3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白（PI3K/AKT/mTOR）信号通路。
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