Kawashima Y, Takegishi M, Watanuki H, Katoh H, Tachibana Y, Kozuka H
Toxicol Appl Pharmacol. 1985 May;78(3):363-9. doi: 10.1016/0041-008x(85)90241-8.
Rats were fed a diet containing clofibric acid or tiadenol. The treatment of rats with clofibric acid caused an increase in the activity of cyanide-insensitive palmitoyl-CoA oxidation and in the concentration of a polypeptide with a molecular weight of about 80,000 in the light mitochondrial fraction in intestinal mucosa. Treatment of rats with tiadenol increased the activity of cyanide-insensitive palmitoyl-CoA oxidation more markedly than with clofibric acid. The induced activity in intestinal mucosa was about 1/10th that in liver. Treatment of rats with either of the two peroxisome proliferators increased both [1-14C]oleic acid binding capacity and the concentration of FABP in intestinal mucosa of rats. The treatment of rats with clofibric acid did not seem to alter the properties of FABP found in intestinal mucosa.
给大鼠喂食含氯贝酸或替阿地诺的饲料。用氯贝酸处理大鼠会导致肠黏膜轻线粒体部分中对氰化物不敏感的棕榈酰辅酶A氧化活性增加，以及一种分子量约为80,000的多肽浓度增加。用替阿地诺处理大鼠比用氯贝酸更显著地增加了对氰化物不敏感的棕榈酰辅酶A氧化活性。肠黏膜中的诱导活性约为肝脏中的1/10。用两种过氧化物酶体增殖剂中的任何一种处理大鼠，都会增加大鼠肠黏膜中[1-14C]油酸结合能力和脂肪酸结合蛋白（FABP）的浓度。用氯贝酸处理大鼠似乎不会改变肠黏膜中发现的FABP的性质。
