Effect of clofibric acid and tiadenol on peroxisomal beta-oxidation and fatty acid binding protein in intestinal mucosa of rats.

Rats were fed a diet containing clofibric acid or tiadenol. The treatment of rats with clofibric acid caused an increase in the activity of cyanide-insensitive palmitoyl-CoA oxidation and in the concentration of a polypeptide with a molecular weight of about 80,000 in the light mitochondrial fraction in intestinal mucosa. Treatment of rats with tiadenol increased the activity of cyanide-insensitive palmitoyl-CoA oxidation more markedly than with clofibric acid. The induced activity in intestinal mucosa was about 1/10th that in liver. Treatment of rats with either of the two peroxisome proliferators increased both [1-14C]oleic acid binding capacity and the concentration of FABP in intestinal mucosa of rats. The treatment of rats with clofibric acid did not seem to alter the properties of FABP found in intestinal mucosa.