铜死亡及与铜死亡相关的细胞死亡和基因：与生精细胞死亡的机制联系
Cuproptosis and cuproptosis-related cell death and genes: mechanistic links to spermatogenic cell death.
作者信息
Li Junjun, Li Nihong, Wang Hong, Li Bin, Tang Xinyi, Guan Yanxin, Yang Fang, Li Guangsen, Dong Liang, Yuan Renbin, Yu Xujun
机构信息
Chengdu Fifth People's Hospital/The Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Ziyang Yanjiang People's Hospital, Ziyang, China.
出版信息
Cell Death Discov. 2025 Jun 10;11(1):274. doi: 10.1038/s41420-025-02553-2.
Spermatogenesis, which is regulated by multiple cell death mechanisms, is an extremely complex process. The significance of cell death during spermatogenesis is a topic of interest because of its potential medical implications. Cuproptosis is a new mechanism of cell death discovered in recent years, and recent studies have preliminarily confirmed that cuproptosis is involved in the process of spermatogenic cell death, but its specific role in the process of spermatogenic cell death is still unclear. In this review, the mechanisms of spermatogenic cell death associated with cuproptosis and the effects of key genes of cuproptosis on spermatogenesis are discussed together with some new perspectives for the study of spermatogenic cell death.
精子发生受多种细胞死亡机制调控，是一个极其复杂的过程。由于其潜在的医学意义，精子发生过程中细胞死亡的重要性是一个备受关注的话题。铜死亡是近年来发现的一种新的细胞死亡机制，近期研究初步证实铜死亡参与了生精细胞死亡过程，但其在生精细胞死亡过程中的具体作用仍不清楚。在这篇综述中，我们将讨论与铜死亡相关的生精细胞死亡机制、铜死亡关键基因对精子发生的影响，以及生精细胞死亡研究的一些新观点。
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