Şahin İlknur, Batur Şebnem, Üstündağ Ahmet, Arapi Berk, Tel Üstünışık Çiğdem, Göksedef Deniz, Ömeroğlu Suat Nail, İpek Gökhan, Balkanay Ozan Onur
Basaksehir Cam Ve Sakura City Hospital, Cardiovascular Surgery Clinic, University of Health Sciences, Istanbul, Turkey.
Cerrahpasa Medical Faculty, Department of Medical Pathology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Cardiovasc Toxicol. 2025 Jun 10. doi: 10.1007/s12012-025-10017-3.
It is known that COVID-19 patients may experience endothelial cell inflammation, apoptosis, dysfunction, and systemic coagulation disorders. In CABG operations, graft patency plays a crucial role in survival and morbidity. Thrombosis and endothelial cell inflammation in grafts can pose challenges for CABG candidates with a history of COVID-19. This study aimed to evaluate the vasculitic effects of a history of COVID-19 among CABG patients. A total of 94 consecutive patients, including 34 with a history of COVID-19 and 60 without, who were scheduled for CABG at our clinic, were included in the study after informed consent was obtained. Patients with a history of COVID-19 underwent surgery at least 4 weeks after the recovery of infection. Thromboembolic events were monitored throughout the hospital stay, and vascular grafts obtained during surgery were pathologically evaluated for signs of vasculitis and inflammation. All COVID-19 (n = 34) cases were mild. Statistical analysis revealed no significant difference between the groups regarding vein thrombosis/thrombophlebitis (p = 0.626). Additionally, pathological evaluation showed no signs of vasculitis or inflammation. There were also no significant differences in postoperative mortality and morbidity between the two groups (p > 0.05). Based on our findings, undergoing CABG surgery after a four-week recovery period appears to be safe for patients with a history of mild COVID-19, at least in terms of early postoperative vascular outcomes.
众所周知，新冠病毒病（COVID-19）患者可能会出现内皮细胞炎症、凋亡、功能障碍以及全身凝血障碍。在冠状动脉旁路移植术（CABG）手术中，移植物通畅对患者的生存和发病情况起着关键作用。移植物中的血栓形成和内皮细胞炎症可能给有COVID-19病史的CABG手术候选者带来挑战。本研究旨在评估COVID-19病史对CABG患者的血管炎影响。本研究纳入了94例连续的患者，包括34例有COVID-19病史的患者和60例无该病史的患者，这些患者均在我们诊所计划接受CABG手术，并在获得知情同意后纳入研究。有COVID-19病史的患者在感染恢复后至少4周接受手术。在整个住院期间监测血栓栓塞事件，并对手术中获取的血管移植物进行病理评估，以检查血管炎和炎症迹象。所有COVID-19病例（n = 34）均为轻症。统计分析显示，两组在静脉血栓形成/血栓性静脉炎方面无显著差异（p = 0.626）。此外，病理评估未显示血管炎或炎症迹象。两组术后死亡率和发病率也无显著差异（p > 0.05）。根据我们的研究结果，对于有轻症COVID-19病史的患者，在四周恢复期后进行CABG手术似乎是安全的，至少在术后早期血管结局方面如此。
