Zhao Karen, Fournier Renée, Kennedy Kevin, Grocott Hilary P, Belley-Côté Emilie, Cameron Matthew, Whitlock Richard P, Brudney C Scott, Janda Allison M, Jacobsohn Eric, Mazer C David, Lamontagne François, Smith Christie, Guyatt Gordon, Spence Jessica
Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
School of Population and Public Health, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Can J Anaesth. 2025 Jun;72(6):895-903. doi: 10.1007/s12630-025-02971-x. Epub 2025 Jun 10.
Clinicians presume a relationship between the management of blood pressure during cardiac surgery and postoperative morbidity and mortality. With limited evidence to inform practice, we surveyed Canadian cardiac anesthesiologists, perfusionists, and cardiac surgeons. We sought to solicit information to inform a trial evaluating the blood pressure management approach on outcomes after cardiac surgery.
We iteratively developed a survey assessing the lowest and highest blood pressures respondents would target, the narrowest feasible blood pressure range to achieve, the range of blood pressure observed in clinical practice, and factors influencing targeted blood pressure before, during, and after cardiopulmonary bypass (CPB). We contacted leads from every Canadian hospital providing cardiac surgery to distribute the survey via a computerized link. We used a modified Dillman approach to optimize response rate. Responses were analyzed descriptively.
Of 819 clinicians surveyed, 532 (65%) responded. Respondents' lowest pooled mean arterial pressure (MAP) target, presented as mean (standard deviation [SD]), was 59 (6) mm Hg before CPB, 55 (7) mm Hg during CPB, and 60 (5) mm Hg after CPB. Respondents' highest pooled MAP target, presented as mean (SD), was 92 (10) mm Hg before CPB, 84 (7) mm Hg during CPB, and 75 (6) mm Hg after CPB. The narrowest feasible MAP range, presented as mean (SD), all respondents believed could be achieved was 19 (7) mm Hg before CPB, 16 (7) mm Hg during CPB, and 20 (7) mm Hg after CPB.
The responses to our survey support the clinical acceptability of a trial examining blood pressure target thresholds at the extreme ends of the range recommended by existing guidelines and the feasibility of maintaining blood pressure within a narrow target range.
临床医生推测心脏手术期间血压管理与术后发病率和死亡率之间存在关联。由于指导实践的证据有限,我们对加拿大心脏麻醉医生、灌注师和心脏外科医生进行了调查。我们旨在收集信息,为一项评估心脏手术后血压管理方法对预后影响的试验提供依据。
我们反复制定了一项调查问卷,评估受访者的最低和最高血压目标、可实现的最窄可行血压范围、临床实践中观察到的血压范围,以及体外循环(CPB)前、期间和之后影响目标血压的因素。我们联系了加拿大每家提供心脏手术的医院的负责人,通过计算机链接分发调查问卷。我们采用改良的迪尔曼方法来优化回复率。对回复进行描述性分析。
在819名接受调查的临床医生中,532名(65%)做出了回复。受访者汇总的最低平均动脉压(MAP)目标,以平均值(标准差[SD])表示,CPB前为59(6)mmHg,CPB期间为55(7)mmHg,CPB后为60(5)mmHg。受访者汇总的最高MAP目标,以平均值(SD)表示,CPB前为92(10)mmHg,CPB期间为84(7)mmHg,CPB后为75(6)mmHg。所有受访者认为可实现的最窄可行MAP范围,以平均值(SD)表示,CPB前为19(7)mmHg,CPB期间为16(7)mmHg,CPB后为20(7)mmHg。
我们的调查回复支持了一项试验的临床可接受性,该试验研究现有指南推荐范围两端的血压目标阈值,以及将血压维持在狭窄目标范围内的可行性。