He Xian-Ming, Jiang Si-Cong, Luo Qi-Wei, Ding Jian-Wu, Hu Rong-Huan, Hu Jia-Li, Liu Meng-Meng, Tao Lei, Zhang Jian-Ze, Wu Jia-Yin, Deng Su, Zeng Lei
Department of Oncology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People's Republic of China.
The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People's Republic of China.
Eur J Med Res. 2025 Jun 11;30(1):473. doi: 10.1186/s40001-025-02745-7.
This preliminary study explores the prognostic value of pretreatment peripheral serum apolipoprotein E (ApoE) in patients with non-metastatic nasopharyngeal carcinoma (NPC).
A retrospective collection of pretreatment indicators was conducted for 352 nasopharyngeal carcinoma patients between January 2016 and December 2020. Receiver operating characteristic curve analysis, univariate and multivariate Cox proportional hazards analysis were all utilized to assess the correlation between blood ApoE and overall survival (OS), progression-free survival (PFS), distant metastasis-free survival (DMFS) and local recurrence-free survival (LRFS).
A higher baseline serum ApoE level (> 71.5 mg/L) was markedly associated with poorer OS (HR = 2.255, 95% CI 1.232-4.125, P = 0.008) and remained an independent prognostic factor in multivariate Cox regression analysis. Additionally, body mass index (BMI), body surface area (BSA), Epstein-Barr virus (EBV)DNA load, and high-density lipoprotein cholesterol (HDL-C) were also identified as independent predictors of nasopharyngeal carcinoma prognosis.
An elevated pretreatment serum ApoE level is indicative of a poorer prognosis for nasopharyngeal carcinoma patients and is independent of other known prognostic factors. These findings highlight the value of ApoE as a potential biomarker for risk stratification and personalized treatment in nasopharyngeal carcinoma.
本初步研究探讨治疗前外周血清载脂蛋白E（ApoE）在非转移性鼻咽癌（NPC）患者中的预后价值。
回顾性收集了2016年1月至2020年12月期间352例鼻咽癌患者的治疗前指标。采用受试者工作特征曲线分析、单因素和多因素Cox比例风险分析来评估血液ApoE与总生存期（OS）、无进展生存期（PFS）、无远处转移生存期（DMFS）和无局部复发生存期（LRFS）之间的相关性。
较高的基线血清ApoE水平（>71.5mg/L）与较差的OS显著相关（HR=2.255，95%CI 1.232-4.125，P=0.008），并且在多因素Cox回归分析中仍然是一个独立的预后因素。此外，体重指数（BMI）、体表面积（BSA）、EB病毒（EBV）DNA载量和高密度脂蛋白胆固醇（HDL-C）也被确定为鼻咽癌预后的独立预测因素。
治疗前血清ApoE水平升高表明鼻咽癌患者预后较差，且独立于其他已知的预后因素。这些发现凸显了ApoE作为鼻咽癌风险分层和个性化治疗潜在生物标志物的价值。
