卵巢组织的冷冻保存与移植作为癌症后组织治疗及卵子发生激活剂
Cryopreservation and transplantation of ovarian tissue as post-cancer tissue therapy and an activator of oogenesis.
作者信息
Isachenko Volodimir, Morgenstern Bernd, Todorov Plamen, Isachenko Evgenia, Nawroth Frank, Quassdorff Maria, Salama Mahmoud, Mallmann-Gottschalk Nina, Merzenich Markus, Skala Christine, Rahimi Gohar
机构信息
Department of Obstetrics and Gynecology, Medical Faculty, Cologne University, Cologne, Germany.
Institute of Biology and Immunology of Reproduction of Bulgarian Academy of Sciences (BAS), Sofia, Bulgaria.
出版信息
J Ovarian Res. 2025 Jun 10;18(1):128. doi: 10.1186/s13048-025-01680-9.
In a recent publication (Reprod. Biomed. Online, 2024) it was presented point of view that, for post-cancer patients, in vitro fertilization (IVF) is a more effective method than ovarian tissue cryopreservation (OTC). In their commentary, Andersen et al. (Reprod. Biomed. Online, 2024) present nine distinct arguments advocating for the use of OTC. We fully agree with all these points. In support of the clinical application of the OTC procedure, we introduce two additional arguments. First, the transplantation of cryopreserved ovarian tissue can be considered as a form of tissue therapy. Moreover, OTC inherently serves as an activator of oogenesis. Second, during tissue dissection prior to OTC, a significant number of germinal vesicle (GV) oocytes can be retrieved, matured to the metaphase II (MII) stage, cryopreserved, and later used in IVF procedures.
在最近的一篇出版物（《生殖生物医学在线》，2024年）中，有人提出了这样一种观点，即对于癌症后患者，体外受精（IVF）是一种比卵巢组织冷冻保存（OTC）更有效的方法。在他们的评论中，安徒生等人（《生殖生物医学在线》，2024年）提出了九个不同的论据来支持使用OTC。我们完全同意所有这些观点。为了支持OTC程序的临床应用，我们提出另外两个论据。第一，冷冻保存的卵巢组织移植可被视为一种组织治疗形式。此外，OTC本身就是卵子发生的激活剂。第二，在OTC之前的组织解剖过程中，可以获取大量生发泡（GV）卵母细胞，使其成熟到中期II（MII）阶段，进行冷冻保存，随后用于IVF程序。
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