Khan Rashid Nehal, Kinra Prateek, Kumar Naveen, Radhakrishna K V, Khera Anurag, Kashif A W, Anandhakrishnan T, Manral Ishita
Associate Professor, Department of FMT, Armed Forces Medical College, Pune, India.
Professor (Pathology), Air Headquarter, RK Puram, New Delhi, India.
Med J Armed Forces India. 2025 Mar-Apr;81(2):163-169. doi: 10.1016/j.mjafi.2023.12.009. Epub 2024 Mar 12.
Body mass index (BMI) is a critical determinant of mortality, and higher BMI is associated with coronary artery disease (CAD) and chronic kidney disease (CKD).
An autopsy-based prospective descriptive pilot study conducted over 02 years. All the cases of age between 18 and 70 years without any known comorbidities were considered for the study. BMI was calculated and during autopsy heart was examined for any coronary artery stenosis and kidney were examined grossly and sent for histopathology examination.
This study has a male predominance, with 73.1 % male and 26.9 % female. Maximum cases were in age group 51-60 years (25 %). 60.6 % cases were in normal BMI and 39.4 % cases were in abnormal BMI. Left anterior descending artery (LAD) was the most commonly involved artery with stenosis >50 %. Glomerulosclerosis was present in 8.65 % cases and tubular atrophy was present in 6.73 % cases. When normal BMI vs abnormal BMI was compared with LAD (p 0.00), LCX (p 0.01) and RCA (p 0.01) stenosis, tubular atrophy (p 0.05), strong association was found and when compared with glomerulosclerosis (p 0.13) no association was found.
There is a strong connection between BMI and both CAD and CKD, although the degree and nature of these connections can vary depending on several factors. To have complete assessment of one's risk factors for CAD and CKD, it is crucial to undergo regular health check-ups and engage in conversations with healthcare professional.
体重指数（BMI）是死亡率的关键决定因素，较高的BMI与冠状动脉疾病（CAD）和慢性肾脏病（CKD）相关。
一项基于尸检的前瞻性描述性试点研究，为期两年。研究纳入所有年龄在18至70岁之间且无任何已知合并症的病例。计算BMI，并在尸检时检查心脏是否存在冠状动脉狭窄，对肾脏进行大体检查并送去做组织病理学检查。
本研究男性占主导，男性占73.1%，女性占26.9%。最大病例数在51 - 60岁年龄组（25%）。60.6%的病例BMI正常，39.4%的病例BMI异常。左前降支动脉（LAD）是最常受累的动脉，狭窄>50%。8.65%的病例存在肾小球硬化，6.73%的病例存在肾小管萎缩。当比较正常BMI与异常BMI时，发现与LAD狭窄（p<0.00）、左旋支（LCX）狭窄（p<0.01）和右冠状动脉（RCA）狭窄（p<0.01）、肾小管萎缩（p<0.05）有强关联，而与肾小球硬化（p = 0.13）无关联。
BMI与CAD和CKD之间存在紧密联系，尽管这些联系的程度和性质可能因多种因素而异。为了全面评估一个人患CAD和CKD的风险因素，定期进行健康检查并与医疗保健专业人员进行沟通至关重要。
