Ogolla Jared Otieno, Masinde David Rocaztle, Mbeke Alexander Munyao
Department of Public Health, School of Public Health and Community Development, Maseno University, Private Bag, Maseno, Kenya.
Department of Biological and Biomedical Sciences, School of Science, Laikipia University, PO Box 1100-20300, Nyahururu, Kenya.
Ecancermedicalscience. 2025 Apr 15;19:1892. doi: 10.3332/ecancer.2025.1892. eCollection 2025.
The human papillomavirus (HPV) vaccine is a critical public health measure designed to reduce the incidence of HPV-related cancers, particularly cervical cancer. Despite its proven efficacy, vaccine uptake remains suboptimal in many areas, including Korogocho ward, a densely populated informal settlement in Nairobi County, Kenya. This study explored factors influencing HPV vaccine uptake among girls aged 9-14 in Korogocho. A total of 812 caretakers participated, identified through snowball sampling during the baseline survey of the Health Awareness, Learning and Education (HEALEDUC) intervention. The HEALEDUC initiative, a quasi-experimental study, employed intervention and control groups with pre- and post-intervention assessments to evaluate strategies for improving HPV vaccination rates in the region. Key findings revealed that caretaker age significantly impacted vaccination decisions ( = 0.022). Caretakers aged 35-44 were more likely to vaccinate their children (OR = 1.930, 95% CI = 0.790-4.716), although no consistent patterns emerged among other age groups. Interestingly, uncertainty about HPV transmission was associated with higher vaccine uptake (OR = 2.024, 95% CI = 1.107-3.701, = 0.022). Negative perceptions of healthcare workers' attitudes strongly correlated with increased vaccination likelihood (OR = 4.883, 95% CI = 1.834-12.999, = 0.002). Satisfaction with healthcare services demonstrated borderline significance ( = 0.059). Conversely, distance to healthcare facilities ( = 0.348) and transport costs ( = 0.873) were not statistically significant determinants of vaccine uptake. However, caretakers residing more than 10 km from healthcare facilities exhibited slightly higher odds of vaccinating their children (OR = 3.136, 95% CI = 0.521-18.881). These findings underscore the importance of targeted interventions to bridge knowledge gaps, foster trust in healthcare systems and improve interactions between caretakers and healthcare providers. Addressing these factors can enhance HPV vaccine uptake in resource-limited settings.
人乳头瘤病毒（HPV）疫苗是一项关键的公共卫生措施，旨在降低HPV相关癌症的发病率，尤其是宫颈癌。尽管其疗效已得到证实，但在包括肯尼亚内罗毕县人口密集的非正式定居点科罗戈乔区在内的许多地区，疫苗接种率仍不理想。本研究探讨了影响科罗戈乔区9至14岁女孩HPV疫苗接种的因素。共有812名看护人参与，他们是在健康意识、学习与教育（HEALEDUC）干预的基线调查期间通过滚雪球抽样确定的。HEALEDUC倡议是一项准实验研究，采用干预组和对照组，并进行干预前后评估，以评估提高该地区HPV疫苗接种率的策略。主要研究结果显示，看护人的年龄对疫苗接种决策有显著影响（P = 0.022）。35至44岁的看护人更有可能为其子女接种疫苗（OR = 1.930，95% CI = 0.790 - 4.716），不过其他年龄组未出现一致模式。有趣的是，对HPV传播的不确定性与更高的疫苗接种率相关（OR = 2.024，95% CI = 1.107 - 3.701，P = 0.022）。对医护人员态度的负面看法与接种疫苗可能性增加密切相关（OR = 4.883，95% CI = 1.834 - 12.999，P = 0.002）。对医疗服务的满意度显示出临界显著性（P = 0.059）。相反，到医疗设施的距离（P = 0.348）和交通成本（P = 0.873）在统计学上并非疫苗接种的显著决定因素。然而，居住在距离医疗设施超过10公里处的看护人为其子女接种疫苗的几率略高（OR = 3.136，95% CI = 0.521 - ）。这些研究结果强调了有针对性的干预措施对于弥合知识差距、增强对医疗系统的信任以及改善看护人与医疗服务提供者之间互动的重要性。解决这些因素可以提高资源有限地区HPV疫苗的接种率。
