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具有非典型组织病理学表现的色素沉着性皮肤病变提示黑色素瘤多发转移的诊断：一例报告。

Pigmented skin lesions with atypical histopathology indicating a diagnosis of multiple metastases of melanoma: A case report.

作者信息

He Yun, Fan Huanfang, Du Zhihua, Li Dehui, Gu Yiting, Liu Zihui

机构信息

The Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050011, P.R. China.

Second Department of Oncology, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050011, P.R. China.

出版信息

Oncol Lett. 2025 May 27;30(1):369. doi: 10.3892/ol.2025.15115. eCollection 2025 Jul.

DOI:10.3892/ol.2025.15115
PMID:40496544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12150006/
Abstract

The present study reports on the case of a middle-aged female patient who presented with a rapidly progressing pigmented skin lesion on the periphery, combined with multiple intracranial, pulmonary, hepatic and skeletal malignancies. The case was not clear in terms of histopathological manifestations and other aspects, which made the diagnosis of melanoma difficult. The present case details the challenges in the diagnostic process, as well as the importance of multidisciplinary comprehensive diagnosis and treatment, aiming to provide a reference for clinicians when dealing with similar complex pigmented skin lesions.

摘要

本研究报告了一名中年女性患者的病例，该患者外周出现迅速进展的色素沉着性皮肤病变，并伴有多发颅内、肺、肝和骨骼恶性肿瘤。该病例在组织病理学表现等方面不明确，这使得黑色素瘤的诊断困难。本病例详细介绍了诊断过程中的挑战以及多学科综合诊断和治疗的重要性，旨在为临床医生处理类似复杂的色素沉着性皮肤病变时提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/9a5290481b06/ol-30-01-15115-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/d00975c68f91/ol-30-01-15115-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/32e4641685f6/ol-30-01-15115-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/6654bca83bef/ol-30-01-15115-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/2fe211b32aea/ol-30-01-15115-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/c11ac552faa2/ol-30-01-15115-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/cc1dd128d3a6/ol-30-01-15115-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/13448da14892/ol-30-01-15115-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/9a5290481b06/ol-30-01-15115-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/d00975c68f91/ol-30-01-15115-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/32e4641685f6/ol-30-01-15115-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/6654bca83bef/ol-30-01-15115-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/2fe211b32aea/ol-30-01-15115-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/c11ac552faa2/ol-30-01-15115-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/cc1dd128d3a6/ol-30-01-15115-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/13448da14892/ol-30-01-15115-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b5/12150006/9a5290481b06/ol-30-01-15115-g07.jpg

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Neurocutaneous Melanosis with Meningeal Melanocytosis: A Rare Case of Intracranial Hypertension and Cutaneous Manifestations.伴有脑膜黑素细胞增多症的神经皮肤黑素沉着症：一例罕见的颅内高压和皮肤表现病例。
Life (Basel). 2024 Jan 18;14(1):139. doi: 10.3390/life14010139.
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Combining Biomarkers for the Diagnosis of Metastatic Melanoma.
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Tumour-infiltrating lymphocyte therapy for patients with advanced-stage melanoma.肿瘤浸润淋巴细胞治疗晚期黑色素瘤患者。
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CAR NK Cell Therapy for the Treatment of Metastatic Melanoma: Potential & Prospects.嵌合抗原受体自然杀伤（CAR-NK）细胞疗法治疗转移性黑色素瘤：潜力与展望。
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