Irace Concetta, Avogaro Angelo, Bertuzzi Federico, Buzzetti Raffaella, Candido Riccardo, Del Prato Stefano, Di Bartolo Paolo, Fiorina Paolo, Giorda Carlo Bruno, Giorgino Francesco
Department of Health Science, University Magna Græcia, Catanzaro, Italy.
Department of Medicine, University of Padua, Padua, Italy.
Diabetes Metab Res Rev. 2025 Jul;41(5):e70059. doi: 10.1002/dmrr.70059.
Type 2 diabetes (T2D) is a pandemic and strongly impact patients' prognosis. Several barriers may hamper the achievement of good glycaemic control, which is the aim of diabetes care. These include but are not limited to poor treatment adherence, poor self-management, and heterogeneity of the disease context. Diabetes self-management is critical, particularly in insulin-treated patients and it is largely based on glucose monitoring, which allows recording glucose levels to make informed decisions with respect to meals, exercise, and other daily-life activities. For decades, glucose monitoring has been based on self-measurement of capillary blood glucose, which has some obvious important limitations. With the start of the new century, systems for continuous glucose monitoring (CGM) have become available. These systems measure subcutaneous interstitial glucose levels in a continuous or intermittent manner. They allow a better description of daily glucose pattern and glycaemic trend, a more accurate identification of glucose peaks and identification of otherwise unrecognised hypoglycaemic episodes, and a more reliable assessment of the stability of glycaemic control. CGM has been repeatedly shown to improve glycaemic control and reduce the risk of hypoglycaemia in type 1 diabetes (T1D). Over the years however, evidence has been gathered on the CGM use in T2D on different treatment regimens and wider applications are clearly desired. The aim of this expert opinion paper is to summarise the currently available evidence on CGM use across the whole spectrum of T2D and suggest practical indications beyond current guidelines.
2型糖尿病(T2D)是一种大流行病,对患者的预后有重大影响。实现良好的血糖控制是糖尿病治疗的目标,但存在一些障碍可能会妨碍这一目标的实现。这些障碍包括但不限于治疗依从性差、自我管理不善以及疾病背景的异质性。糖尿病自我管理至关重要,尤其是在接受胰岛素治疗的患者中,其很大程度上基于血糖监测,通过记录血糖水平,以便就饮食、运动和其他日常生活活动做出明智的决策。几十年来,血糖监测一直基于毛细血管血糖的自我测量,这存在一些明显的重要局限性。随着新世纪的到来,连续血糖监测(CGM)系统已可供使用。这些系统以连续或间歇的方式测量皮下组织间液葡萄糖水平。它们能更好地描述每日血糖模式和血糖趋势,更准确地识别血糖峰值以及发现其他未被识别的低血糖事件,更可靠地评估血糖控制的稳定性。CGM已多次被证明可改善1型糖尿病(T1D)患者的血糖控制并降低低血糖风险。然而,多年来,关于CGM在不同治疗方案的T2D患者中的应用已有证据积累,显然需要更广泛的应用。本专家意见论文的目的是总结目前关于CGM在整个T2D范围内应用的现有证据,并提出超出当前指南的实际应用指征。