Sandoval Gonzalez Saitiel, Song Weilin, Privratsky Joseph K, Lemon Jack, Tsui Edmund
Department of Ophthalmology, UCLA Stein Eye Institute, Los Angeles, California, USA.
David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Ocul Immunol Inflamm. 2025 Oct;33(8):1834-1836. doi: 10.1080/09273948.2025.2514693. Epub 2025 Jun 11.
To describe the appearance and resolution of a vascularized iris nodule in a case of ocular syphilis with swept-source anterior segment optical coherence tomography (SS AS-OCT) imaging.
Case report.
A 73-year-old male with a history of ocular syphilis presented with anterior uveitis of the left eye characterized by mutton fat keratic precipitates, anterior chamber cells, hypopyon mixed with hemorrhage, and a vascularized iris nodule. SS AS-OCT similarly showed keratic precipitates, anterior chamber cells, and an iris lesion with anterior hyperreflectivity and shadowing. Systemic workup revealed a new syphilis infection with rapid plasma reagin (RPR) titer of 1:512. After completing a 14-day course of intravenous penicillin and topical steroid treatment, there was resolution of these ocular findings.
Ocular syphilis should be considered on the differential diagnosis for vascularized iris lesions. Our case demonstrates SS-AS-OCT findings in this rare presentation of ocular syphilis.
通过扫频源眼前节光学相干断层扫描（SS AS-OCT）成像描述1例眼梅毒患者中血管化虹膜结节的表现及消退情况。
病例报告。
一名有眼梅毒病史的73岁男性，左眼出现前葡萄膜炎，表现为羊脂状角膜后沉着物、前房细胞、伴有出血的前房积脓以及一个血管化虹膜结节。SS AS-OCT同样显示出角膜后沉着物、前房细胞以及一个虹膜病变，该病变表现为前部高反射性和遮蔽现象。全身检查发现新的梅毒感染，快速血浆反应素（RPR）滴度为1:512。在完成14天的静脉青霉素和局部类固醇治疗疗程后，这些眼部表现消退。
在血管化虹膜病变的鉴别诊断中应考虑眼梅毒。我们的病例展示了这种罕见的眼梅毒表现的SS-AS-OCT检查结果。
