Coombs Jared R, Burgener Sabrina S, Schroder Kate
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072, Australia.
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072, Australia.
Immunity. 2025 Jun 10;58(6):1372-1374. doi: 10.1016/j.immuni.2025.05.017.
Red blood cells (RBCs) undergo pathological cell death in hemolytic diseases. In a recent issue of Cell, Chen et al. reveal a mode of programmed cell death, spectosis, in which complement activation initiates (mini)NLRP3-caspase-8 complexes, culminating in hemolysis.
红细胞(RBCs)在溶血性疾病中会发生病理性细胞死亡。在最近一期的《细胞》杂志上,陈等人揭示了一种程序性细胞死亡模式——“spectosis”,其中补体激活启动(微小)NLRP3 - 半胱天冬酶 - 8复合物,最终导致溶血。