Siekmann U, Daschner F, Heilmann L
Z Geburtshilfe Perinatol. 1985 May-Jun;189(3):119-24.
Between 1978 and 1984 we performed 3 122 amniocentesis for prenatal diagnosis in second trimester. Based on a four week follow-up in more than 96% of all amniocentesis the percentage of fetal loss was 0.74% (n = 23). In 13 cases abortion was accompanied by chorioamnionitis. These cases were examined for various technical details and it could be concluded, that the incidence of febrile abortion is related to the early gestational age for amniocentesis. On the other hand, multiple insertions or the localisation of placenta both show no relation to the short-time febrile complications. To investigate the maternal-fetal transfer of mezlocillin, a single dose of 5 g mezlocillin was administered intravenously in 25 patients. In amniotic fluid mezlocillin levels exceeded 2 micrograms/ml nearly 120 minutes after administration. These pharmacokinetic data suggest, that a prophylactic regimen with antibiotics in the course of amniocentesis seems not to be beneficial for the prevention of chorio-amniotic infections.
1978年至1984年间，我们在孕中期进行了3122次羊膜腔穿刺术以进行产前诊断。在超过96%的羊膜腔穿刺术病例中进行了为期四周的随访，胎儿丢失率为0.74%（n = 23）。13例流产伴有绒毛膜羊膜炎。对这些病例的各种技术细节进行了检查，可以得出结论，发热性流产的发生率与羊膜腔穿刺术时的孕周有关。另一方面，多次穿刺或胎盘定位与短期发热并发症均无关联。为研究美洛西林的母婴转运情况，对25例患者静脉注射了5g单剂量美洛西林。给药后近120分钟，羊水中美洛西林水平超过2μg/ml。这些药代动力学数据表明，在羊膜腔穿刺术过程中使用抗生素进行预防性治疗似乎对预防绒毛膜羊膜感染没有益处。
