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使用短波红外荧光成像和吲哚菁绿对猫脂肪肉瘤进行术中可视化。

Intraoperative visualization of feline liposarcoma using short-wave infrared fluorescence imaging and indocyanine green.

作者信息

Kim Jihun, Kim Yujin, Park Kyung-Mee, Lee Sungin

机构信息

Department of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.

Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.

出版信息

J Vet Med Sci. 2025 Aug 1;87(8):894-897. doi: 10.1292/jvms.25-0113. Epub 2025 Jun 11.

DOI:10.1292/jvms.25-0113
PMID:40500172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12344296/
Abstract

A 9-year-old domestic short hair cat presented with a firm thoracic mass suspected to be a lipoma. Preoperative indocyanine green was administered intravenously at a dose of 5 mg/kg for short-wave infrared fluorescence imaging. Intraoperatively, a plaque-like lipoma overlaid a subjacent mass that exhibited strong fluorescence. Both were excised, and histopathology confirmed the subjacent mass as a well-differentiated liposarcoma. The cat recovered uneventfully with no recurrence at 11 months. This case highlights the utility of short-wave infrared fluorescence imaging in distinguishing benign from malignant tissues intraoperatively and enabling precise resection. To our knowledge, this is the first report of feline liposarcoma identified through short-wave infrared fluorescence imaging, demonstrating its potential as a valuable tool in veterinary oncology.

摘要

一只9岁的家养短毛猫出现一个坚硬的胸部肿块,怀疑是脂肪瘤。术前静脉注射吲哚菁绿,剂量为5mg/kg,用于短波红外荧光成像。术中,一个斑块状脂肪瘤覆盖在下方一个发出强烈荧光的肿块上。两者均被切除,组织病理学证实下方肿块为高分化脂肪肉瘤。这只猫术后恢复顺利,11个月时无复发。该病例突出了短波红外荧光成像在术中区分良性和恶性组织以及实现精确切除方面的实用性。据我们所知,这是通过短波红外荧光成像识别猫脂肪肉瘤的首例报告,证明了其作为兽医肿瘤学中有价值工具的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8457/12344296/f95f1e27aba9/jvms-87-8-894-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8457/12344296/677c205f445e/jvms-87-8-894-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8457/12344296/f95f1e27aba9/jvms-87-8-894-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8457/12344296/677c205f445e/jvms-87-8-894-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8457/12344296/f95f1e27aba9/jvms-87-8-894-g002.jpg

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本文引用的文献

1
Imaging guided adrenalectomy with Indocyanine green fluorescence in a dog with a pheochromocytoma.犬嗜铬细胞瘤应用吲哚菁绿荧光成像引导肾上腺切除术。
J Vet Sci. 2024 Jul;25(4):e53. doi: 10.4142/jvs.24146.
2
Excision of a gastrointestinal stromal tumour in a dog using short-wave infrared fluorescence imaging and indocyanine green.使用短波近红外荧光成像和吲哚菁绿切除犬的胃肠道间质瘤。
Vet Med Sci. 2024 Jul;10(4):e1506. doi: 10.1002/vms3.1506.
3
Intraoperative near-infrared fluorescence guided surgery using indocyanine green (ICG) may aid the surgical removal of benign bone and soft tissue tumours.
术中近红外荧光引导吲哚菁绿(ICG)的使用可能有助于良性骨和软组织肿瘤的手术切除。
Surg Oncol. 2024 Aug;55:102091. doi: 10.1016/j.suronc.2024.102091. Epub 2024 May 28.
4
Intraoperative Evaluation of Soft Tissue Sarcoma Surgical Margins with Indocyanine Green Fluorescence Imaging.吲哚菁绿荧光成像用于软组织肉瘤手术切缘的术中评估
Cancers (Basel). 2023 Jan 18;15(3):582. doi: 10.3390/cancers15030582.
5
Clinical impact of near-infrared fluorescence imaging with indocyanine green on surgical treatment for hepatic masses in dogs.应用吲哚菁绿近红外荧光成像技术对犬肝脏肿块手术治疗的临床影响。
BMC Vet Res. 2022 Oct 19;18(1):374. doi: 10.1186/s12917-022-03467-2.
6
NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green.近红外荧光引导下的肿瘤手术:吲哚菁绿的新应用策略。
Int J Nanomedicine. 2019 Sep 25;14:7823-7838. doi: 10.2147/IJN.S207486. eCollection 2019.
7
Well-differentiated inflammatory liposarcoma with metastasis in a 6-y-old cat.一只6岁猫的高分化炎性脂肪肉瘤伴转移
J Vet Diagn Invest. 2017 Nov;29(6):896-899. doi: 10.1177/1040638717725349. Epub 2017 Aug 6.
8
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J Am Vet Med Assoc. 2015 Dec 15;247(12):1404-7. doi: 10.2460/javma.247.12.1404.
9
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