西班牙队列中中度冠状动脉病变充血分数血流储备指数与非充血静息全周期比率指数不一致的预测因素
Predictors of Discordance Between the Hyperemic Fractional Flow Reserve Index and the Nonhyperemic Resting Full-Cycle Ratio Index in Intermediate Coronary Lesions in a Spanish Cohort.
作者信息
Guirao Balsalobre María Del Carmen, Bruno Pérez Tomás, Valcárcel Amante Ana, Cano Vivar Pedro, Dau Villareal Derek, Abellán Huerta José, Ramos Martín Jose Luis, Cascón Pérez Jose Domingo, Castillo Moreno Juan Antonio
机构信息
Servicio de Cardiología, Hospital Universitario Santa Lucía, Cartagena, Murcia, España.
出版信息
Catheter Cardiovasc Interv. 2025 Aug;106(2):1282-1290. doi: 10.1002/ccd.31682. Epub 2025 Jun 11.
BACKGROUND AND AIMS
The use of fractional flow reserve (FFR) and resting full-cycle ratio (RFR) for assessing intermediate coronary lesions is well-established. However, discordance between these methods occurs in 15%-25% of cases. The objective is to identify clinical and angiographic predictors of discordance between FFR and RFR in a Spanish cohort.
METHODS
A prospective cohort study of 94 patients with 107 intermediate coronary lesions was conducted. FFR and RFR were measured, and logistic regression was used to identify predictors of discordance.
RESULTS
Discordance occurred in 15.9% of cases. Independent predictors were active smoking, lesions in the left anterior descending artery, and higher area stenosis percentage.
CONCLUSION
Smoking, LAD lesions, and stenosis severity predict discordance between FFR and RFR. Further studies are needed to clarify the phenomena that cause such discordance.
背景与目的
使用血流储备分数（FFR）和静息全周期比值（RFR）评估中度冠状动脉病变已得到广泛认可。然而，在15%-25%的病例中，这些方法之间存在不一致。目的是在西班牙队列中确定FFR和RFR之间不一致的临床和血管造影预测因素。
方法
对94例患有107处中度冠状动脉病变的患者进行了一项前瞻性队列研究。测量了FFR和RFR，并使用逻辑回归来确定不一致的预测因素。
结果
15.9%的病例出现不一致。独立预测因素为当前吸烟、左前降支病变和较高的面积狭窄百分比。
结论
吸烟、左前降支病变和狭窄严重程度可预测FFR和RFR之间的不一致。需要进一步研究以阐明导致这种不一致的现象。
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