Neuberger M, Ambrosch P, Kundi M
Zentralbl Bakteriol Mikrobiol Hyg B. 1985 Jun;181(1-2):81-6.
In a cohort study on 324 asbestos cement workers an increased risk of lung cancer was observed in comparison to cement workers (O/E = 1.7, p less than 0.05). 10 out of 17 deaths from lung cancer occurred after age 65, stressing the need for screening after retirement. In a pilot study on 198 asbestos cement workers we tried to adjust the screening intensity to individual risk (esp. for respiratory and gastrointestinal diseases) by use of history (exposure, smoking, etc.) and results of earlier examination. We found relations between smoking and respiratory symptoms, smoking and parameters of flow-volume-curves, smoking and radiological signs of early pneumoconiosis. Possibilities for early detection and intervention are discussed.
在一项针对324名石棉水泥工人的队列研究中,与水泥工人相比,观察到肺癌风险增加(观察值/预期值 = 1.7,p小于0.05)。17例肺癌死亡中有10例发生在65岁之后,这凸显了退休后进行筛查的必要性。在一项针对198名石棉水泥工人的试点研究中,我们试图通过利用病史(接触史、吸烟史等)和早期检查结果,将筛查强度调整至个体风险(尤其是呼吸和胃肠道疾病风险)。我们发现吸烟与呼吸道症状、吸烟与流量-容积曲线参数、吸烟与早期尘肺病影像学征象之间存在关联。文中讨论了早期检测和干预的可能性。