[异种血清制剂致敏活性的比较研究]
[Comparative study of the sensitizing activity of heterologous serum preparations].
作者信息
Nemov V V
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 1985 Jul(7):63-7.
PMID:4050218
Abstract
Experiments on guinea pigs and adrenalectomized mice showed that the anaphylactogenic properties xenogenic immunoglobulin preparations were 2- to 2.5-fold higher than those of antitoxic sera "Diaferm-3". The partial acid-enzymatic hydrolysis of immunoglobulin preparations obtained by ethanol fractionation permitted a considerable decrease in their sensitizing activity and anticomplementary properties.
摘要
对豚鼠和肾上腺切除小鼠的实验表明，异种免疫球蛋白制剂的过敏原性比“Diaferm - 3”抗毒素血清高2至2.5倍。通过乙醇分级分离获得的免疫球蛋白制剂进行部分酸酶水解，可使其致敏活性和抗补体特性大幅降低。
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