Taranov V A
Zh Mikrobiol Epidemiol Immunobiol. 1985 Jul(7):80-3.
The immunostimulating effect of corpuscular pertussis vaccine on the antigen-presenting and bactericidal functions of peritoneal and splenic macrophages in CBA and C57BL/6 mice, differing in the intensity of immune response to sheep red blood cells and Salmonella typhimurium, has been studied. The study has revealed that the injection of pertussis vaccine alters the functional activity of the cells under study, the effect depending on the immunizing dose, the strain of mice and the time elapsed from the moment of immunization. Pertussis vaccine enhances the low capacity of macrophages for antigen presentation in C57BL/6 mice with low responsiveness and alters the resistance of peritoneal and splenic macrophages to the cytopathic action of salmonellae.
研究了微粒百日咳疫苗对CBA和C57BL/6小鼠腹膜和脾脏巨噬细胞的抗原呈递及杀菌功能的免疫刺激作用，这两种小鼠对绵羊红细胞和鼠伤寒沙门氏菌的免疫反应强度不同。研究发现，注射百日咳疫苗会改变所研究细胞的功能活性，其效果取决于免疫剂量、小鼠品系以及免疫后经过的时间。百日咳疫苗增强了低反应性C57BL/6小鼠巨噬细胞低水平的抗原呈递能力，并改变了腹膜和脾脏巨噬细胞对沙门氏菌细胞病变作用的抵抗力。
