Al-Ghaithi Ahmed M, Al-Barkhati Sara, Al Abri Al Munqith, Al Husaini Doaa, Al-Hajri Abdallah, Al-Saadi Tariq
Department Neurosurgery, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 132, Sultanate of Oman.
Department of Ophthalmology, Sultan Qaboos University Hospital, Muscat 132, Sultanate of Oman.
Med Int (Lond). 2025 May 28;5(4):46. doi: 10.3892/mi.2025.245. eCollection 2025 Jul-Aug.
The present study aimed to systematically review and analyze the available literature on patients with glioblastoma (GBM) receiving palliative care. A systemic literature review was thus conducted searching for patients with GBM receiving palliative care using the following databases: PubMed, Scopus, Wiley and Web of Science. All articles relevant to the review were included, covering all age groups and types of palliative care used in all settings, and there was no time limit. A total of 234 studies were obtained from the search that matched the objectives of the review. A total of 19 articles were included, ranging from 1998 to 2022, with a total number of 7,392 patients. Supportive treatment was one approach to palliative and end-of-life care in patients with GBM; other approaches included chemotherapy, surgery and radiotherapy. The location of the mortality of patients with GBM differed between hospitals and health institutes, homes and hospice care. Out of 19 studies included, 10 of these reported hospitals to be the place of mortality. Patients with GBM have a poor prognosis, with a poor survival rate, even with the optimal treatment available. Moreover, multiple signs and symptoms can burden the end-of-life of patients and their families. Palliative care in these patients aims to relieve the burden of end-of-life care and improve the quality of life of the patients and their families.
本研究旨在系统回顾和分析关于胶质母细胞瘤（GBM）患者接受姑息治疗的现有文献。因此，进行了一项系统的文献综述，使用以下数据库搜索接受姑息治疗的GBM患者：PubMed、Scopus、Wiley和Web of Science。纳入了所有与该综述相关的文章，涵盖所有年龄组以及在所有环境中使用的姑息治疗类型，且没有时间限制。通过搜索获得了总共234项符合综述目标的研究。总共纳入了19篇文章，时间跨度从1998年至2022年，患者总数为7392例。支持性治疗是GBM患者姑息治疗和临终关怀的一种方法；其他方法包括化疗、手术和放疗。GBM患者的死亡地点在医院与卫生机构、家庭和临终关怀机构之间有所不同。在纳入的19项研究中，其中10项报告医院是死亡地点。GBM患者预后较差，即使采用了最佳可用治疗，生存率也很低。此外，多种体征和症状会给患者及其家人的临终生活带来负担。这些患者的姑息治疗旨在减轻临终护理的负担，提高患者及其家人的生活质量。
