Zhang Yanzi, Lv Xin
Clinical Laboratory, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, P.R. China.
Clinical Laboratory, Jinan Children's Hospital, Jinan, Shandong 250022, P.R. China.
Oncol Lett. 2025 Jun 3;30(2):379. doi: 10.3892/ol.2025.15125. eCollection 2025 Aug.
Insulin-like growth factor binding protein 3 (IGFBP3) is the primary carrier of circulating insulin-like growth factors and is the most extensively studied protein among the six high-affinity insulin-like growth factor binding proteins. Alterations in IGFBP3 at both the transcriptional and post-translational levels may contribute to the occurrence and progression of tumors. The present review focused on the changes in expression levels of IGFBP3 in tumors, as well as the relationship between the activation and inhibition of associated cell signaling pathways, and alterations in cellular biological behavior, aiming to provide a reference for the precise treatment of tumors.
胰岛素样生长因子结合蛋白3（IGFBP3）是循环胰岛素样生长因子的主要载体，也是六种高亲和力胰岛素样生长因子结合蛋白中研究最为广泛的蛋白。IGFBP3在转录和翻译后水平的改变可能促进肿瘤的发生和进展。本综述聚焦于IGFBP3在肿瘤中的表达水平变化，以及相关细胞信号通路的激活与抑制之间的关系，还有细胞生物学行为的改变，旨在为肿瘤的精准治疗提供参考。
