• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Targeting FANCM using the antisense oligonucleotides to treat the ALT-positive cancers.

作者信息

Naji Shakir, Tong Christopher, Ragupathi Ashwin, Xiao Ming, Zhang Dong

机构信息

Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY 11568, USA.

Center for Cancer Research, New York Institute of Technology, Old Westbury, NY 11568, USA.

出版信息

Mol Ther Nucleic Acids. 2025 May 23;36(2):102558. doi: 10.1016/j.omtn.2025.102558. eCollection 2025 Jun 10.

DOI:10.1016/j.omtn.2025.102558
PMID:40503178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12152324/
Abstract
摘要

相似文献

1
Targeting FANCM using the antisense oligonucleotides to treat the ALT-positive cancers.使用反义寡核苷酸靶向FANCM以治疗端粒延长替代途径(ALT)阳性癌症。
Mol Ther Nucleic Acids. 2025 May 23;36(2):102558. doi: 10.1016/j.omtn.2025.102558. eCollection 2025 Jun 10.
2
Targeting FANCM by antisense oligonucleotides in ALT-positive cancers.在端粒酶替代途径(ALT)阳性癌症中通过反义寡核苷酸靶向FANCM
Mol Ther Nucleic Acids. 2025 Feb 20;36(2):102492. doi: 10.1016/j.omtn.2025.102492. eCollection 2025 Jun 10.
3
DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres.DNA2和FANCM在破坏TERRA R环和抑制ALT端粒处的复制应激的两条不同途径中发挥作用。
bioRxiv. 2025 May 24:2025.05.22.655602. doi: 10.1101/2025.05.22.655602.
4
FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres.FANCM、BRCA1 和 BLM 协同作用解决 ALT 端粒的复制应激。
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5940-E5949. doi: 10.1073/pnas.1708065114. Epub 2017 Jul 3.
5
SLX4IP acts in parallel to FANCM to limit BLM-dependent replication stress at ALT telomeres.SLX4IP与FANCM协同作用,以限制ALT端粒处依赖BLM的复制应激。
bioRxiv. 2025 May 29:2025.05.28.656696. doi: 10.1101/2025.05.28.656696.
6
FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops.FANCM 通过限制 BLM 和 R 环引起的端粒复制应激来限制 ALT 活性。
Nat Commun. 2019 May 28;10(1):2253. doi: 10.1038/s41467-019-10179-z.
7
FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops.FANCM 通过破坏 TERRA R-环来抑制 ALT 端粒处的 DNA 复制应激。
Sci Rep. 2019 Dec 13;9(1):19110. doi: 10.1038/s41598-019-55537-5.
8
ALTernative Functions for Human FANCM at Telomeres.人类FANCM在端粒的替代功能。
Front Mol Biosci. 2019 Sep 6;6:84. doi: 10.3389/fmolb.2019.00084. eCollection 2019.
9
Potent Cyclic Peptide Inhibitors Disrupt the FANCM-RMI Interaction.强效环肽抑制剂破坏FANCM-RMI相互作用。
J Med Chem. 2025 Jun 26;68(12):12615-12625. doi: 10.1021/acs.jmedchem.5c00365. Epub 2025 Jun 6.
10
Inhibitory effect of 2'-o-methoxyethyl-modified antisense oligonucleotides targeting vascular endothelial growth factor A on SKOV3 human ovarian cancer cells.靶向血管内皮生长因子 A 的 2'-O-甲氧基乙基修饰反义寡核苷酸对 SKOV3 人卵巢癌细胞的抑制作用。
Chin Med J (Engl). 2011 May;124(10):1573-5.

本文引用的文献

1
Comprehensive interrogation of synthetic lethality in the DNA damage response.对DNA损伤反应中合成致死性的全面探究。
Nature. 2025 Apr;640(8060):1093-1102. doi: 10.1038/s41586-025-08815-4. Epub 2025 Apr 9.
2
Targeting FANCM by antisense oligonucleotides in ALT-positive cancers.在端粒酶替代途径(ALT)阳性癌症中通过反义寡核苷酸靶向FANCM
Mol Ther Nucleic Acids. 2025 Feb 20;36(2):102492. doi: 10.1016/j.omtn.2025.102492. eCollection 2025 Jun 10.
3
Detection of Alternative Lengthening of Telomeres via Chromogenic In Situ Hybridization for the Prognostication of PanNETs and Other Neoplasms.
通过显色原位杂交检测端粒替代延长用于胰腺神经内分泌肿瘤和其他肿瘤的预后评估
Mod Pathol. 2025 Mar;38(3):100651. doi: 10.1016/j.modpat.2024.100651. Epub 2024 Nov 9.
4
Profound synthetic lethality between SMARCAL1 and FANCM.SMARCAL1与FANCM之间存在显著的合成致死性。
Mol Cell. 2024 Dec 5;84(23):4522-4537.e7. doi: 10.1016/j.molcel.2024.10.016. Epub 2024 Nov 6.
5
Mechanisms of Alternative Lengthening of Telomeres.端粒替代延长机制
Cold Spring Harb Perspect Biol. 2025 Jan 7;17(1):a041690. doi: 10.1101/cshperspect.a041690.
6
Single-Molecule Telomere Assay via Optical Mapping (SMTA-OM) Can Potentially Define the ALT Positivity of Cancer.通过光学作图的单分子端粒分析(SMTA-OM)可能能够定义癌症的 ALT 阳性。
Genes (Basel). 2023 Jun 16;14(6):1278. doi: 10.3390/genes14061278.
7
Targeting the / deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights.用聚(ADP-核糖)聚合酶(PARP)抑制剂靶向缺陷型癌症:临床结果与机制洞察
Front Cell Dev Biol. 2023 Mar 22;11:1133472. doi: 10.3389/fcell.2023.1133472. eCollection 2023.
8
Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cells.端粒过度延伸促进端粒酶阳性人细胞中环 DNA 的形成。
J Biol Chem. 2023 May;299(5):104665. doi: 10.1016/j.jbc.2023.104665. Epub 2023 Mar 30.
9
Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers.端粒复制应激:端粒的替代延长与癌症的开始和结束。
Open Biol. 2022 Mar;12(3):220011. doi: 10.1098/rsob.220011. Epub 2022 Mar 9.
10
ALT Positivity in Human Cancers: Prevalence and Clinical Insights.人类癌症中的谷丙转氨酶阳性:患病率及临床见解
Cancers (Basel). 2021 May 14;13(10):2384. doi: 10.3390/cancers13102384.