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Altered Bone Morphogenetic Protein 2 Signaling Causes Age-Dependent Decline in Gut Motility Independent of Muscularis Macrophages.

作者信息

Bishop Estelle Spear, Morley Logan, Janakiraman Mathangi, Vikram Anya, Namkoong Hong, Becker Laren

机构信息

Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, California.

Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington, Vermont.

出版信息

Gastro Hep Adv. 2025 Apr 11;4(7):100673. doi: 10.1016/j.gastha.2025.100673. eCollection 2025.

DOI:10.1016/j.gastha.2025.100673
PMID:40503185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12158492/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/12158492/904814f22399/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/12158492/cb3fbdb43059/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/12158492/904814f22399/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/12158492/cb3fbdb43059/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3a/12158492/904814f22399/gr2.jpg

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本文引用的文献

1
Organization of the human intestine at single-cell resolution.人类肠道的单细胞分辨率组织图谱
Nature. 2023 Jul;619(7970):572-584. doi: 10.1038/s41586-023-05915-x. Epub 2023 Jul 19.
2
Dedicated macrophages organize and maintain the enteric nervous system.特化的巨噬细胞组织并维持肠神经系统。
Nature. 2023 Jun;618(7966):818-826. doi: 10.1038/s41586-023-06200-7. Epub 2023 Jun 14.
3
Age-dependent Microglial Disease Phenotype Results in Functional Decline in Gut Macrophages.年龄依赖性小胶质细胞疾病表型导致肠道巨噬细胞功能衰退。
Gastro Hep Adv. 2023;2(2):261-276. doi: 10.1016/j.gastha.2022.09.006. Epub 2022 Sep 29.
4
Aging of enteric neuromuscular systems in gastrointestinal tract.胃肠道肠神经肌肉系统的老化。
Neurogastroenterol Motil. 2022 Jun;34(6):e14352. doi: 10.1111/nmo.14352. Epub 2022 Mar 13.
5
Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.不同的间充质细胞群体产生必需的肠道 BMP 信号梯度。
Cell Stem Cell. 2020 Mar 5;26(3):391-402.e5. doi: 10.1016/j.stem.2020.01.008. Epub 2020 Feb 20.
6
Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.自维持肠道巨噬细胞对于肠道稳态至关重要。
Cell. 2018 Oct 4;175(2):400-415.e13. doi: 10.1016/j.cell.2018.07.048. Epub 2018 Aug 30.
7
Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system.年龄相关的巨噬细胞极化转变导致炎症介导的肠神经退行性变。
Gut. 2018 May;67(5):827-836. doi: 10.1136/gutjnl-2016-312940. Epub 2017 Feb 21.
8
Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility.肌间巨噬细胞与肠神经元之间的串扰调节胃肠道运动。
Cell. 2014 Jul 17;158(2):300-313. doi: 10.1016/j.cell.2014.04.050.
9
Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit.骨形态发生蛋白对肠神经元表型多样性的调节：与细胞周期退出时间的关系。
J Comp Neurol. 2008 Aug 10;509(5):474-92. doi: 10.1002/cne.21770.
10
Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice.在转基因小鼠中通过诱导型Cre介导的基因敲除进行单神经元标记。
Nat Neurosci. 2008 Jun;11(6):721-8. doi: 10.1038/nn.2118. Epub 2008 May 4.