Nevakivi Reetta, Siiskonen Hanna, Haimakainen Salla, Harvima Ilkka T
Department of Dermatology University of Eastern Finland and Kuopio University Hospital Kuopio Finland.
Department of Pathology Kuopio University Hospital Kuopio Finland.
Health Sci Rep. 2025 Jun 11;8(6):e70888. doi: 10.1002/hsr2.70888. eCollection 2025 Jun.
Melanocytic nevi (MN) and atypical melanocytic nevi (AMN) are established risk factors for cutaneous malignant melanoma (CMM), with patients exhibiting atypical mole syndrome (AMS) facing an even greater risk. Peripheral blood biomarkers-including neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-lymphocyte ratio (ELR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)-have been linked to various cancers, including CMM. This cross-sectional study aimed to investigate the relationship between these biomarkers and MN and AMS, which are common phenotypes among melanoma patients.
A total of 505 subjects (aged 21-79, 254 males and 249 females, 96 with immunosuppression) at elevated risk of any type of skin cancer were examined for MN, AMN, level of cutaneous photodamage, and other potential confounding factors. A peripheral blood sample was analyzed for blood cells.
PLR levels were significantly higher in subjects with more than 50 nevi or AMS. In multivariable logistic regression models, high PLR was significantly associated with having more than 50 melanocytic nevi (OR: 2.015, 95% CI: 1.159-3.501, = 0.01) and with atypical mole syndrome (OR: 4.092, 95% CI: 2.012-8.323, < 0.001). Other significant factors associated with high MN density and AMS were lower age, male sex, higher BMI, no immunosuppression, and fewer actinic keratoses. However, NLR, ELR, and SII showed no relation to MN or AMS.
This study demonstrates a statistically significant association between elevated PLR and the presence of more than 50 MN or AMS, whereas no associations were observed with NLR, ELR, or SII. This specific relationship suggests that PLR may have particular relevance in the context of multiple MN and AMS, potentially influencing its interpretation in melanoma prognosis. However, further studies are needed to validate this finding, explore underlying biological mechanisms, and assess causality.
黑素细胞痣（MN）和非典型黑素细胞痣（AMN）是皮肤恶性黑色素瘤（CMM）的既定危险因素，患有非典型痣综合征（AMS）的患者面临的风险更高。外周血生物标志物，包括中性粒细胞与淋巴细胞比值（NLR）、嗜酸性粒细胞与淋巴细胞比值（ELR）、血小板与淋巴细胞比值（PLR）以及全身免疫炎症指数（SII），已与包括CMM在内的多种癌症相关联。这项横断面研究旨在调查这些生物标志物与MN和AMS之间的关系，MN和AMS是黑色素瘤患者中常见的表型。
对总共505名有任何类型皮肤癌高风险的受试者（年龄21 - 79岁，男性254名，女性249名，96名有免疫抑制）进行MN、AMN、皮肤光损伤程度及其他潜在混杂因素的检查。采集外周血样本分析血细胞。
痣超过50个或患有AMS的受试者PLR水平显著更高。在多变量逻辑回归模型中，高PLR与黑素细胞痣超过50个显著相关（比值比：2.015，95%置信区间：1.159 - 3.501，P = 0.01），与非典型痣综合征相关（比值比：4.092，95%置信区间：2.012 - 8.323，P < 0.001）。与高MN密度和AMS相关的其他显著因素包括年龄较小、男性、较高的体重指数、无免疫抑制以及较少的光化性角化病。然而，NLR、ELR和SII与MN或AMS无关。
本研究表明PLR升高与50个以上MN或AMS的存在之间存在统计学上的显著关联，而未观察到与NLR、ELR或SII有关联。这种特定关系表明PLR在多个MN和AMS的背景下可能具有特殊相关性，可能会影响其在黑色素瘤预后中的解读。然而，需要进一步研究来验证这一发现，探索潜在的生物学机制，并评估因果关系。
