Sorrentino Francesco Saverio, Parmeggiani Francesco, Gardini Lorenzo, Fontana Luigi, Musa Mutali, Gagliano Caterina, Zeppieri Marco
Department of Surgical Sciences, Unit of Ophthalmology, Ospedale Maggiore, Bologna 40100, Italy.
Department of Translational Medicine and for Romagna, University of Ferrara, Ferrara 44121, Italy.
World J Stem Cells. 2025 May 26;17(5):103100. doi: 10.4252/wjsc.v17.i5.103100.
Retinal pigment epithelium (RPE) dysfunction is involved in the advancement of numerous degenerative retinal illnesses, such as age-related macular degeneration and hereditary retinal abnormalities. Transplantation of RPE produced from stem cells has emerged as a promising therapeutic strategy to restore retinal function and prevent vision loss. However, other obstacles impede its clinical application, including immunological rejection, cell viability, functional integration, and the necessity for consistent differentiation techniques. This review offers a thorough examination of the molecular processes regulating RPE integrity, investigates recent progress in stem cell-derived RPE therapeutics, and addresses significant challenges to their broad implementation. Furthermore, we emphasize prospective avenues intended to enhance the safety, efficacy, and enduring success of RPE transplantation in clinical environments.
视网膜色素上皮（RPE）功能障碍与多种退行性视网膜疾病的进展有关，如年龄相关性黄斑变性和遗传性视网膜异常。干细胞来源的RPE移植已成为一种有前景的治疗策略，用于恢复视网膜功能和预防视力丧失。然而，其他障碍阻碍了其临床应用，包括免疫排斥、细胞活力、功能整合以及对一致分化技术的需求。本综述全面审视了调节RPE完整性的分子过程，研究了干细胞来源的RPE治疗的最新进展，并探讨了其广泛应用面临的重大挑战。此外，我们强调了旨在提高临床环境中RPE移植的安全性、有效性和持久成功率的潜在途径。
