Jørgensen L, Nordal E J, Eide T J, Svendsen E A, Bostad L H, Engh T V, Blom G P
Acta Pathol Microbiol Immunol Scand A. 1985 Sep;93(5):251-5. doi: 10.1111/j.1699-0463.1985.tb03948.x.
With the aim of examining the possible association between atherosclerosis of the aorta and renal scarring, an autopsy study comprising 81 men and 43 women was performed. The per cent intimal surface involved with atherosclerosis in the aorta above the renal arteries was determined by morphometry, and the per cent surface profile of the kidney affected by scarring was measured microscopically in a standardized fashion. In addition, the following variables were determined: the age of the patient, diameter of the renal artery ostia, weight of the kidneys, heart weight, presence or absence of signs of sustained myocardial infarction, highest measured systolic blood pressure and the number of macroscopic renal scars. The data were subjected to both simple correlation and multiple regression analyses. In both men and women there was a significant simple correlation between the degree of atherosclerosis in the aorta and the extent of subcapsular microscopic renal scarring. In men, the prime importance of aortic atherosclerosis for microscopic renal scarring was supported in the multiple regression analysis. In women, this analysis showed that age was the determining predictive factor for microscopical renal scarring. The results may be taken to support the hypothesis that micro-embolism from an atherosclerotic aorta may be a cause of microscopic subcapsular scars in the kidneys.
为了研究主动脉粥样硬化与肾瘢痕形成之间可能存在的关联，我们对81名男性和43名女性进行了尸检研究。通过形态计量学确定肾动脉上方主动脉中发生动脉粥样硬化的内膜表面积百分比，并以标准化方式在显微镜下测量受瘢痕影响的肾脏表面轮廓百分比。此外，还确定了以下变量：患者年龄、肾动脉开口直径、肾脏重量、心脏重量、是否存在持续性心肌梗死迹象、最高测量收缩压以及肉眼可见的肾瘢痕数量。对数据进行了简单相关分析和多元回归分析。在男性和女性中，主动脉粥样硬化程度与肾包膜下显微镜下肾瘢痕形成程度之间均存在显著的简单相关性。在男性中，多元回归分析支持主动脉粥样硬化对显微镜下肾瘢痕形成的首要重要性。在女性中，该分析表明年龄是显微镜下肾瘢痕形成的决定性预测因素。这些结果可能支持以下假设：来自动脉粥样硬化主动脉的微栓塞可能是肾脏包膜下显微镜下瘢痕形成的原因。
