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Paternal Preconception Metformin Use and Offspring Risk of Congenital Malformations.

作者信息

Huybrechts Krista F, Straub Loreen, Rotem Ran S, Bateman Brian T, Hernández-Díaz Sonia

机构信息

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

出版信息

JAMA Netw Open. 2025 Jun 2;8(6):e2515002. doi: 10.1001/jamanetworkopen.2025.15002.

DOI:10.1001/jamanetworkopen.2025.15002
PMID:40504532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12163650/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c2/12163650/80a927e0ee6a/jamanetwopen-e2515002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c2/12163650/80a927e0ee6a/jamanetwopen-e2515002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c2/12163650/80a927e0ee6a/jamanetwopen-e2515002-g001.jpg

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本文引用的文献

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2
Paternal Use of Metformin During the Sperm Development Period Preceding Conception and Risk for Major Congenital Malformations in Newborns.父亲在受孕前的精子发育期使用二甲双胍与新生儿重大先天畸形风险。
Ann Intern Med. 2024 Jul;177(7):851-861. doi: 10.7326/M23-1405. Epub 2024 Jun 18.
3
Adverse Birth and Child Outcomes in Children Fathered by Men Treated with Antidiabetics Prior to Conception: A Nationwide Cohort Study.
受孕前接受抗糖尿病药物治疗的男性所育子女的不良出生和儿童结局：一项全国性队列研究。
J Clin Med. 2022 Nov 7;11(21):6595. doi: 10.3390/jcm11216595.
4
Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring : A Nationwide Cohort Study.男性孕前使用降糖药物与子代出生缺陷：一项全国性队列研究。
Ann Intern Med. 2022 May;175(5):665-673. doi: 10.7326/M21-4389. Epub 2022 Mar 29.
5
Identifying pregnancies in insurance claims data: Methods and application to retinoid teratogenic surveillance.在保险理赔数据中识别妊娠情况：方法及其在维甲酸致畸监测中的应用。
Pharmacoepidemiol Drug Saf. 2019 Sep;28(9):1211-1221. doi: 10.1002/pds.4794. Epub 2019 Jul 22.
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Validity of maternal and infant outcomes within nationwide Medicaid data.全国医疗补助数据中母婴结局的有效性
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