Sagharichi Mastooreh, Aalipour Mohammad Amin, Eghbal Elahe, Javandoust Gharehbagh Farid, Shadidi Asil Roozbe, Alavi Darazam Ilad
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of General Surgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Neuroimmunol. 2025 Sep 15;406:578662. doi: 10.1016/j.jneuroim.2025.578662. Epub 2025 Jun 7.
Common Variable Immunodeficiency (CVID) is a primary immunodeficiency disorder that often presents with recurrent infections and autoimmune complications, leading to diagnostic delays. This case report presents two adult male patients, ages 44 and 42, with prolonged histories of recurrent pneumonia, sinusitis, meningitis, and autoimmune encephalitis. Both cases were initially mismanaged due to the isolated treatment of symptoms, delaying the diagnosis of CVID. Comprehensive diagnostic evaluations eventually revealed low immunoglobulin levels, confirming the diagnosis. These cases highlight the importance of early recognition and a multidisciplinary approach to managing patients with recurrent infections and unusual presentations.
