Pineda Edith Nathalie, Nounamo Bernice, Du Ruofei, Larrey Enoch K, Gilreath Cordell, Cook Harrison, Boerma Marjan, Koturbash Igor, Pathak Rupak
Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
NPJ Microgravity. 2025 Jun 12;11(1):24. doi: 10.1038/s41526-025-00480-1.
Given NASA's plans for manned lunar and Mars missions, it is critical to assess the risk of splenic immune dysregulation by using ground-based models of simulated microgravity (SMG) and/or chronic irradiation (CIR). To address this, C57BL/6 J mice of both sexes exposed to SMG and/or CIR for 29 days and alterations in immune cell distribution, function and phenotype were assessed. SMG and/or CIR altered a greater variety of immune cells in both lymphoid and myeloid lineages in female mice than in male mice; the function of splenic CD4 + T cells, CD8 + T cells, and CD19 + B cells altered in a sex-specific manner; and the distribution of different immune cells altered based on animal sex. These findings indicate that SMG and/or CIR alter the splenic immune cell distribution, phenotype and function in a sex-specific manner, underscoring the need for tailored strategies to mitigate health risks for crew members on long-term deep-space missions.
鉴于美国国家航空航天局（NASA）的载人月球和火星任务计划，利用地面模拟微重力（SMG）和/或慢性辐射（CIR）模型评估脾脏免疫失调风险至关重要。为解决这一问题，对暴露于SMG和/或CIR环境29天的雌雄C57BL/6 J小鼠进行了评估，观察其免疫细胞分布、功能和表型的变化。与雄性小鼠相比，SMG和/或CIR对雌性小鼠淋巴系和髓系中更多种类的免疫细胞产生了影响；脾脏CD4 + T细胞、CD8 + T细胞和CD19 + B细胞的功能以性别特异性方式发生改变；不同免疫细胞的分布也因动物性别而异。这些发现表明，SMG和/或CIR以性别特异性方式改变脾脏免疫细胞的分布、表型和功能，强调需要制定针对性策略，以降低长期深空任务中机组人员的健康风险。
