Keeling Eloise, Carter Perry, Musa Abdi Malik, Shawkat Fatima, Lee Helena, Self Jay E
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Southampton Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Diagnostics (Basel). 2025 May 30;15(11):1395. doi: 10.3390/diagnostics15111395.
Visual evoked potentials (VEPs) are used to detect chiasmal misrouting associated with albinism. However, VEPs are only performed in specialist centres and typically have long waiting lists. The portable electrophysiology device RETeval shows promise as a clinical screening tool across a range of ophthalmic conditions. Here, we explore its utility in detecting chiasmal abnormalities associated with albinism. Flash VEPs were recorded on the RETeval and by standard ISCEV techniques for 27 patients with suspected albinism and 40 control patients as part of routine appointments. We retrospectively investigated the agreeability between the two methods. The amplitude/latency of the main component was measured for standard VEPs whilst a correlation value of interhemispheric difference was calculated for the RETeval data. We demonstrate a significant difference between albinism patients and controls ( < 0.001) with respect to the interhemispheric difference identified by the RETeval. By applying a threshold of 0.001865 to the correlation value, the RETeval detected chiasmal misrouting in all 27 patients with albinism and had 97% agreeability to standard testing. This study shows the potential of using the RETeval as a clinical tool for the diagnosis of chiasmal anomalies in albinism. The RETeval has significant time/cost savings which could hasten diagnoses.
视觉诱发电位（VEPs）用于检测与白化病相关的视交叉神经纤维错向。然而，VEPs仅在专科中心进行，而且通常等待名单很长。便携式电生理设备RETeval作为一种针对一系列眼科疾病的临床筛查工具显示出了前景。在此，我们探讨其在检测与白化病相关的视交叉异常方面的效用。作为常规检查的一部分，对27例疑似白化病患者和40例对照患者使用RETeval并通过标准国际临床视觉电生理学会（ISCEV）技术记录闪光视觉诱发电位。我们回顾性地研究了这两种方法之间的一致性。对于标准视觉诱发电位，测量其主要成分的振幅/潜伏期，而对于RETeval数据，计算半球间差异的相关值。我们证明，就RETeval所识别的半球间差异而言，白化病患者与对照患者之间存在显著差异（<0.001）。通过将相关值的阈值设为0.001865，RETeval在所有27例白化病患者中均检测出视交叉神经纤维错向，并且与标准检测的一致性达97%。本研究显示了将RETeval用作诊断白化病视交叉异常的临床工具的潜力。RETeval在时间/成本方面有显著节省，这可能会加快诊断速度。
