Noushzady Farzin Falahat, Álvarez Sonia Herrero, Gastardi Joaquín Calatayud, Vara-Ameigeiras Elena María, Amorós Carlota Mazo, Serrano-García Irene, Trancho Florentino Hernando, Sarceda José Ramón Jarabo, Martínez Ana Maria Gómez
Department of Surgery, School of Medicine, Complutense University of Madrid, Avda. Complutense, s/n, 28040 Madrid, Spain.
Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University of Madrid, Avda. Complutense, s/n, 28040 Madrid, Spain.
Cancers (Basel). 2025 May 31;17(11):1850. doi: 10.3390/cancers17111850.
Second primary lung cancer frequently manifests in individuals who have survived head and neck cancer, with this occurrence often being attributed to shared risk factors. The objective of the present study is to compare the prognosis, in terms of survival rate, of patients who presented isolated bronchogenic carcinoma (BC) with that of patients who presented with a personal history of BC and associated oropharyngeal and oral cancer (OAOC). A retrospective longitudinal study was conducted, including all consecutive patients who underwent surgical resection with curative intent for BC in Hospital Clínico San Carlos (HCSC), Madrid, Spain, between December 1989 and December 2024. The survival rate was calculated and compared in two groups of patients: Group 1: 1594 patients with isolated BC and Group 2: 97 patients with BC and OAOC. Group 2 did not show a significant difference in their 60-month survival rate in comparison to Group 1 (HR = 1.23, CI 95% 0.9-1.6) = 0.14. But when comparing the 120-month survival rate, Group 1 showed a significantly higher survival rate (36.4%, CI 95% 33.9-39%) compared to Group 2, (25.54%, CI 95% 17.78-36.7%) HR= 1.28 (CI 95% 1-1.6), = 0.04. Disease-free survival showed a non-significant trend of greater severity among patients with a previous history of OAOC. : Lung cancer patients who presented with OAOC had worse overall survival compared to patients who presented with isolated lung cancer, and a significant difference was observed at 120 months of follow-up.
第二原发性肺癌常出现在头颈部癌症幸存者中，这种情况通常归因于共同的风险因素。本研究的目的是比较孤立性支气管源性癌（BC）患者与有BC病史且伴有口咽和口腔癌（OAOC）患者的生存率预后情况。进行了一项回顾性纵向研究，纳入了1989年12月至2024年12月期间在西班牙马德里圣卡洛斯临床医院（HCSC）接受根治性手术切除BC的所有连续患者。计算并比较了两组患者的生存率：第1组：1594例孤立性BC患者；第2组：97例BC合并OAOC患者。与第1组相比，第2组的60个月生存率无显著差异（HR = 1.23，95%CI 0.9 - 1.6）= 0.14。但在比较120个月生存率时，第1组的生存率显著高于第2组（36.4%，95%CI 33.9 - 39%），第2组为（25.54%，95%CI 17.78 - 36.7%），HR = 1.28（95%CI 1 - 1.6），= 0.04。无病生存期显示，有OAOC病史的患者病情严重程度有不显著的增加趋势。与孤立性肺癌患者相比，合并OAOC的肺癌患者总生存期更差，在随访120个月时观察到显著差异。
