Lin Shen-Che, Chen Jer-Shen, Huang Jih-Hsin, Chiu Kuan-Ming, Chiang Chih-Yao
Department of Cardiovascular Surgery, Cardiovascular Center, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan.
Department of Electrical Engineering, Yuan Ze University, Taoyuan 320315, Taiwan.
J Clin Med. 2025 Jun 1;14(11):3899. doi: 10.3390/jcm14113899.
Surgical aortic valve replacement effectively relieves left ventricular afterload and promotes reverse remodeling in patients with severe aortic stenosis. The Perceval prosthesis offers a hybrid approach, combining complete annular decalcification with sutureless deployment. This design allows for reduced operative times and potentially larger effective orifice areas. However, comparative data with conventional stented bioprosthetic valves remain limited, particularly regarding reverse remodeling, hemodynamic performance, and long-term clinical outcomes. : In this retrospective cohort study, 115 patients underwent aortic valve replacement with either the Perceval valve ( = 44) or conventional stented bovine pericardial valves ( = 71). The Perceval group showed a 100% procedural success rate with no in-hospital mortality, significantly shorter cardiopulmonary bypass and cross-clamp times, larger effective orifice areas, and a lower incidence of patient-prosthesis mismatch. Both groups demonstrated favorable left ventricular mass regression and reverse remodeling. The rates of paravalvular leakage, permanent pacemaker implantation, and redo aortic valve replacement were comparable between groups. Multivariate Cox regression identified the follow-up indexed left ventricular mass as an independent predictor of major adverse cardiac and cerebral events. : In this study, the Perceval valve was associated with promising hemodynamic characteristics and procedural efficiencies, particularly in cases with small aortic annuli and during minimally invasive procedures. The valve was associated with reverse ventricular remodeling and clinical outcomes that appeared similar to those of conventional stented bioprostheses. These observations suggest it may represent a potential alternative option for surgical aortic valve replacement in appropriate clinical scenarios. However, randomized control trials are needed to confirm these associations.
外科主动脉瓣置换术可有效减轻重度主动脉瓣狭窄患者的左心室后负荷,并促进逆向重构。Perceval人工瓣膜提供了一种混合方法,将完全瓣环脱钙与无缝合植入相结合。这种设计可缩短手术时间,并可能扩大有效瓣口面积。然而,与传统带支架生物瓣膜相比的数据仍然有限,尤其是在逆向重构、血流动力学性能和长期临床结果方面。在这项回顾性队列研究中,115例患者接受了主动脉瓣置换术,其中44例使用Perceval瓣膜,71例使用传统带支架牛心包瓣膜。Perceval组手术成功率为100%,无院内死亡,体外循环和主动脉阻断时间显著缩短,有效瓣口面积更大,人工瓣膜-患者不匹配发生率更低。两组均显示出左心室质量的有利下降和逆向重构。两组间瓣周漏、永久性起搏器植入和再次主动脉瓣置换的发生率相当。多因素Cox回归分析确定随访时的左心室质量指数是主要不良心脑血管事件的独立预测因素。在本研究中,Perceval瓣膜具有良好的血流动力学特征和手术效率,特别是在主动脉瓣环较小的病例和微创手术中。该瓣膜与心室逆向重构和临床结果相关,与传统带支架生物瓣膜相似。这些观察结果表明,在适当的临床情况下,它可能是外科主动脉瓣置换的一个潜在替代选择。然而,需要随机对照试验来证实这些关联。