Yang Meiqing, Xie Congkai, Lu Haozi
Zoology Key Laboratory of Hunan Higher Education, College of Life and Environmental Science, Hunan University of Arts and Science, Changde 415000, China.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Int J Mol Sci. 2025 Jun 3;26(11):5368. doi: 10.3390/ijms26115368.
Detection of multiple analytes in biofluids is of significance for early disease diagnosis, effective treatment monitoring, and accurate prognostic assessment. Electrochemical sensors have emerged as a promising tool for the multiplexed detection of biofluids due to their low cost, high sensitivity, and rapid response. Two-dimensional transition metal carbon/nitride MXene, which has the advantages of a large specific surface area, good electrical conductivity, and abundant surface functional groups, has received increasing attention in the electrochemical sensing field. This paper systematically reviews the advances of MXene-based electrochemical sensors for multiplexed detection in biofluids, emphasizing the design of MXene-based electrode materials as well as the strategies for distinguishing multiple signals during simultaneous electrochemical analysis. In addition, this paper critically analyzes the existing challenges of MXene-based electrochemical sensors for multiplexed detection of biofluids and proposes future development directions for this field. The ultimate goal is to improve biofluid multiplexed detection technology for clinical medical applications.
生物流体中多种分析物的检测对于早期疾病诊断、有效治疗监测和准确预后评估具有重要意义。电化学传感器因其低成本、高灵敏度和快速响应，已成为生物流体多重检测的一种有前途的工具。二维过渡金属碳/氮化物MXene具有比表面积大、导电性好和表面官能团丰富等优点，在电化学传感领域受到越来越多的关注。本文系统综述了基于MXene的电化学传感器在生物流体多重检测方面的进展，重点介绍了基于MXene的电极材料设计以及同时电化学分析过程中区分多个信号的策略。此外，本文批判性地分析了基于MXene的电化学传感器在生物流体多重检测方面存在的挑战，并提出了该领域未来的发展方向。最终目标是改进用于临床医学应用的生物流体多重检测技术。
