Richardson B S, Patrick J E, Abduljabbar H
Am J Obstet Gynecol. 1985 Oct 15;153(4):426-31. doi: 10.1016/0002-9378(85)90081-x.
Cerebral oxidative metabolism and blood flow were measured in 14 chronically prepared fetal lambs with changes in fetal electrocortical activity. Myocardial blood flow was also measured with changes in fetal state in order to determine whether metabolic changes observed were organ specific. Samples of preductal arterial and sagittal vein blood were analyzed for oxygen content, blood gases, and pH. Blood flow was measured with a radioactive microsphere technique. Cerebral oxidative metabolism increased significantly from 126 +/- 7 mumol/100 gm/min during the high-voltage electrocortical state to 152 +/- 7 mumol/100 gm-1/min-1 (p less than 0.05) during the low-voltage electrocortical state. The increase in cerebral oxidative metabolism was sustained by an increase in blood flow, 148 +/- 7 ml/100 gm/min to 173 +/- 10 ml/100 gm/min (p less than 0.01), whereas the arterial venous oxygen difference remained unchanged. Changes in myocardial blood flow were in the opposite direction, with a decrease noted during the low-voltage electrocortical state, and were correlated with changes in fetal heart rate. We conclude that cerebral oxidative metabolism is increased during the fetal low-voltage electrocortical state and suggests an important role for the increased incidence of this state during the accelerated growth and development of the brain during the perinatal period.
在14只长期制备的胎羊中，随着胎儿脑电皮质活动的变化，测量了脑氧化代谢和血流量。还测量了胎儿状态变化时的心肌血流量，以确定观察到的代谢变化是否具有器官特异性。分析了导管前动脉和矢状静脉血样中的氧含量、血气和pH值。采用放射性微球技术测量血流量。脑氧化代谢在高电压脑电皮质状态下为126±7μmol/100g/min，在低电压脑电皮质状态下显著增加至152±7μmol/100g·min-1（p<0.05）。脑氧化代谢的增加是由血流量增加维持的，从148±7ml/100g/min增加到173±10ml/100g/min（p<0.01），而动静脉氧差保持不变。心肌血流量的变化方向相反，在低电压脑电皮质状态下出现减少，且与胎儿心率变化相关。我们得出结论，胎儿低电压脑电皮质状态下脑氧化代谢增加，这表明该状态在围产期大脑加速生长发育过程中发生率增加具有重要作用。
