Murdock R H, Chu A, Grubb M, Cobb F R
Am J Physiol. 1985 Oct;249(4 Pt 2):H783-91. doi: 10.1152/ajpheart.1985.249.4.H783.
The effects of permanent circumflex coronary artery occlusion (PO) compared with reestablishing blood flow (OR) at 2 and 6 h after occlusion on the final extent of histological infarction (HI) was assessed in chronically instrumented awake dogs. The relationships between the extent of left ventricular ischemia measured by microsphere techniques and HI in the PO group were used as models to predict the expected infarction in the 2- and 6-h OR groups. Mean HI (+/-SD) in the PO and 6- and 2-h OR groups was 21 +/- 13, 19 +/- 10, and 13 +/- 12% of left ventricular weight, respectively; values were not significantly different. The extent of HI in samples grouped according to epicardial and endocardial layers and ischemic blood flow ranges (0-15, 16-30, 31-50, 51-75% of control region blood flow) was reduced in the 2-h but not 6-h OR group. Analysis of individual animals using total ischemic region blood flow to epicardial and endocardial layers demonstrated that OR at 2 h but not 6 h reduced infarction in most animals but not in certain animals with the largest ischemic regions.
在长期植入仪器的清醒犬中，评估了永久性冠状动脉回旋支闭塞（PO）与闭塞后2小时和6小时恢复血流（OR）对最终组织学梗死范围（HI）的影响。在PO组中，通过微球技术测量的左心室缺血范围与HI之间的关系被用作模型，以预测2小时和6小时OR组的预期梗死情况。PO组、6小时OR组和2小时OR组的平均HI（±标准差）分别为左心室重量的21±13%、19±10%和13±12%；这些值无显著差异。根据心外膜和心内膜层以及缺血血流范围（对照区域血流的0 - 15%、16 - 30%、31 - 50%、51 - 75%）分组的样本中，HI范围在2小时OR组有所减少，但在6小时OR组未减少。使用心外膜和心内膜层的总缺血区域血流对个体动物进行分析表明，2小时OR可减少大多数动物的梗死，但对于某些缺血区域最大的动物则无效，而6小时OR则无此作用。
